硫酸化葡甘露寡糖的结构特征及其抗氧化活性。
Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity.
机构信息
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310023, China.
Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
出版信息
Mar Drugs. 2018 Aug 21;16(9):291. doi: 10.3390/md16090291.
Glucuronomannan oligosaccharides (Gs) were derived from fucoidan, which was extracted from the brown alga . Sulfated glucuronomannan oligosaccharides (SGs) were obtained by the sulfation of Gs. NMR techniques were used to reveal that the order of sulfation was Man-C6 > Man-C4 > Man-C1R > GlcA-C3 > Man-C3 > GlcA-C2. Finally, the antioxidant activities (hydroxyl radical scavenging activity, superoxide radical scavenging activity, reducing power and DPPH radical scavenging activity) of Gs and SGs were determined. The findings showed that the higher the degree of polymerization, the better the activity, except for the hydroxyl radical scavenging activity. In addition, the higher the sulfate content, the lower the activities for the reducing power and DPPH radical scavenging activity. Opposite results were found for the superoxide radical scavenging activity. Finally, compared with fucoidan, most Gs and SGs had higher antioxidant activity, suggesting that they might be good candidates for antioxidants.
葡甘露聚糖低聚糖（Gs）来源于褐藻中提取的岩藻聚糖，经硫酸化后得到硫酸化葡甘露聚糖低聚糖（SGs）。NMR 技术揭示了硫酸化的顺序为 Man-C6 > Man-C4 > Man-C1R > GlcA-C3 > Man-C3 > GlcA-C2。最后，测定了 Gs 和 SGs 的抗氧化活性（羟基自由基清除活性、超氧自由基清除活性、还原力和 DPPH 自由基清除活性）。结果表明，除了羟基自由基清除活性外，聚合度越高，活性越好。此外，还原力和 DPPH 自由基清除活性随硫酸基含量的增加而降低，而超氧自由基清除活性则相反。最后，与岩藻聚糖相比，大多数 Gs 和 SGs 具有更高的抗氧化活性，表明它们可能是良好的抗氧化剂候选物。
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