Schwarzenbach Heidi, Gahan Peter B
Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Fondazione "Enrico Puccinelli" Onlus, 06126 Perugia, Italy.
Noncoding RNA. 2019 Mar 21;5(1):28. doi: 10.3390/ncrna5010028.
The identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provides the possibility of the transfer of such molecules to control activities in the recipient cells. This review concerns a brief overview of the biogenesis of both exosomes and miRNAs together with the movement of such structures between cells. The possible roles of miRNAs in the development and progression of breast, ovarian and prostate cancers are discussed.
外泌体的鉴定、它们与多囊泡体的联系以及它们作为癌症细胞与健康细胞之间信使载体的潜在作用，为细胞间信号传导的研究开辟了一条新途径。此外，其主要携带物可能是微小RNA（miRNA）这一事实，为这些分子转移以控制受体细胞活动提供了可能性。本综述简要概述了外泌体和miRNA的生物发生过程以及这些结构在细胞间的移动。还讨论了miRNA在乳腺癌、卵巢癌和前列腺癌发生发展中的可能作用。
