Department of Chemical Engineering, University of Salamanca, 37008 Salamanca, Spain.
Department of Microbiology and Genetics, University of Salamanca, 37008 Salamanca, Spain.
Int J Mol Sci. 2019 Mar 26;20(6):1502. doi: 10.3390/ijms20061502.
An environmentally friendly technique was used to produce levan-capped silver nanoparticles of about 30 nm (with a loading of 30%) that showed bactericide effect, for and . That effect was mathematically studied with a dose-response model (lethal dose of 12.4 ppm and 6.8 ppm respectively). These silver nanoparticles were subsequently introduced in a gel to create a silver release system with bacteria inhibition activity. Silver release from the gel and its bactericidal activity was theoretically studied to develop a unique model that is able to predict accurately both silver release and lethal dose for any type of bacteria. This model will be useful for performing predictions for future silver in gel applications.
采用环保技术制备了约 30nm 的甘露糖 capped 银纳米粒子（负载量为 30%），对 和 具有杀菌效果。用剂量-反应模型对该效果进行了数学研究（致死剂量分别为 12.4ppm 和 6.8ppm）。随后，将这些银纳米粒子引入凝胶中，创建了具有抑菌活性的银释放体系。从凝胶中释放银及其杀菌活性的理论研究开发了一种独特的模型，该模型能够准确预测任何类型细菌的银释放和致死剂量。该模型将有助于对未来凝胶中银的应用进行预测。
