Marotta Angela, Sarno Eleonora, Del Casale Antonio, Pane Marco, Mogna Luca, Amoruso Angela, Felis Giovanna E, Fiorio Mirta
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Neurology Unit, Neuroscience Department, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Front Psychiatry. 2019 Mar 27;10:164. doi: 10.3389/fpsyt.2019.00164. eCollection 2019.
Recent demonstration that probiotics administration has positive effects on mood state in healthy populations suggests its possible role as an adjunctive therapy for depression in clinical populations and as a non-invasive strategy to prevent depressive mood state in healthy individuals. The present study extends current knowledge on the beneficial effects of probiotics on psychological well-being, as measured by changes in mood (e.g., cognitive reactivity to sad mood, depression, and anxiety), personality dimensions, and quality of sleep, which have been considered as related to mood. For this double-blind, placebo-controlled study 38 healthy volunteers assigned to an experimental or control group assumed a daily dose of a probiotic mixture (containing LF16, LR06, LP01, and BL04) or placebo, respectively, for 6 weeks. Mood, personality dimensions, and sleep quality were assessed four times (before the beginning of the study, at 3 and 6 weeks, and at 3 weeks of washout). A significant improvement in mood was observed in the experimental group, with a reduction in depressive mood state, anger, and fatigue, and an improvement in sleep quality. No between-groups differences were found. These findings corroborate the positive effect of probiotics on mood state and suggest that probiotics administration may improve psychological well-being by ameliorating aspects of mood and sleep quality.
最近的研究表明，益生菌给药对健康人群的情绪状态有积极影响，这表明其可能作为临床人群抑郁症的辅助治疗方法，以及作为预防健康个体抑郁情绪状态的非侵入性策略。本研究通过情绪变化（如对悲伤情绪的认知反应、抑郁和焦虑）、人格维度和睡眠质量的变化来衡量益生菌对心理健康的有益影响，这些因素被认为与情绪有关，从而扩展了当前关于益生菌有益作用的知识。在这项双盲、安慰剂对照研究中，38名健康志愿者被分配到实验组或对照组，分别每天服用益生菌混合物（含有LF16、LR06、LP01和BL04）或安慰剂，持续6周。在研究开始前、3周和6周以及洗脱期3周时对情绪、人格维度和睡眠质量进行了四次评估。实验组的情绪有显著改善，抑郁情绪状态、愤怒和疲劳减少，睡眠质量提高。未发现组间差异。这些发现证实了益生菌对情绪状态的积极作用，并表明服用益生菌可能通过改善情绪和睡眠质量来提高心理健康水平。
