Kizer Megan E, Linhardt Robert J, Chandrasekaran Arun Richard, Wang Xing
Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
The RNA Institute, University at Albany, State University of New York, Albany, NY, 12203, USA.
Small. 2019 Jun;15(26):e1805386. doi: 10.1002/smll.201805386. Epub 2019 Apr 15.
Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA-based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification to enrich or achieve the needed "properties" and make it whole. These modifications total what are categorized as the molecular hero suit of DNA nanotechnology. Like a hero, DNA nanostructures have the ability to put on a suit equipped with honing mechanisms, molecular flares, encapsulated cargoes, a protective body armor, and an evasive stealth mode.
对DNA碱基配对的精确控制已迅速发展成为一个充满各种纳米级结构和装置的领域，这些结构和装置能够实现自动化、进行分子分析、模拟酶促级联反应、生物传感以及药物递送。这个基于DNA的平台已展现出提供新型治疗方法和生物分子分析的潜力，但最终需要巧妙的修饰来丰富或实现所需的“特性”并使其完善。这些修饰总共构成了DNA纳米技术的分子英雄套装。就像英雄一样，DNA纳米结构有能力穿上一套配备了优化机制、分子信号、封装货物、防护性体甲和规避隐身模式的套装。
