类风湿关节炎患者体内的CD5阳性B细胞：佛波酯介导的检测增强作用
CD5 positive B cells in patients with rheumatoid arthritis: phorbol ester mediated enhancement of detection.
作者信息
Youinou P, Mackenzie L, Jouquan J, Le Goff P, Lydyard P M
出版信息
Ann Rheum Dis. 1987 Jan;46(1):17-22. doi: 10.1136/ard.46.1.17.
Abstract
CD5 molecules present on human T cells are detectable but weakly expressed on some human B cells. We have increased the sensitivity of their detection by treating the B enriched cells with phorbol myristic acetate (PMA), a tumour promoting agent. The numbers of CD5+ B cells in the blood of patients with rheumatoid arthritis (RA) were higher than in control blood, and after PMA treatment this was statistically significant. CD5+ B cells were also increased in tonsils, lymph nodes, and spleens after PMA activation. There were no significant differences between the percentages of B cells carrying chi or lambda light chains in their expression of CD5 molecules in patients with RA.
摘要
人T细胞上存在的CD5分子可被检测到，但在一些人B细胞上表达较弱。我们通过用佛波酯（PMA），一种促肿瘤剂，处理富集的B细胞，提高了其检测的灵敏度。类风湿关节炎（RA）患者血液中CD5+B细胞的数量高于对照血液，经PMA处理后，这具有统计学意义。PMA激活后，扁桃体、淋巴结和脾脏中的CD5+B细胞也增加。RA患者中携带κ或λ轻链的B细胞在CD5分子表达上的百分比没有显著差异。
相似文献
1
CD5 positive B cells in patients with rheumatoid arthritis: phorbol ester mediated enhancement of detection.类风湿关节炎患者体内的CD5阳性B细胞：佛波酯介导的检测增强作用
Ann Rheum Dis. 1987 Jan;46(1):17-22. doi: 10.1136/ard.46.1.17.
2
[Expression of T-lymphocyte antigens by serum B lymphocytes in rheumatoid polyarthritis].[类风湿性多关节炎中血清B淋巴细胞的T淋巴细胞抗原表达]
Rev Rhum Mal Osteoartic. 1986 Nov;53(11):643-7.
3
CD5-expressing B lymphocytes in the blood and salivary glands of patients with primary Sjögren's syndrome.原发性干燥综合征患者血液和唾液腺中表达CD5的B淋巴细胞。
J Autoimmun. 1988 Apr;1(2):185-94. doi: 10.1016/0896-8411(88)90025-x.
4
B cell growth and differentiation factors and mechanism of B cell activation.B细胞生长和分化因子以及B细胞激活机制。
Immunol Rev. 1984 Apr;78:97-118. doi: 10.1111/j.1600-065x.1984.tb00478.x.
5
Phenotypic analysis by flow cytometry of surface immunoglobulin light chains and B and T cell antigens in lymph nodes involved with non-Hodgkin's lymphoma.采用流式细胞术对非霍奇金淋巴瘤累及淋巴结的表面免疫球蛋白轻链以及B和T细胞抗原进行表型分析。
Am J Med. 1985 Oct;79(4):445-54. doi: 10.1016/0002-9343(85)90031-2.
6
Expression of CD5 and CD38 by human CD5- B cells: requirement for special stimuli.人CD5阴性B细胞中CD5和CD38的表达：特殊刺激的需求
Eur J Immunol. 1994 Jun;24(6):1426-33. doi: 10.1002/eji.1830240628.
7
B cell growth and differentiation factors.B细胞生长和分化因子。
Methods Enzymol. 1985;116:372-9. doi: 10.1016/s0076-6879(85)16029-5.
8
Stimulatory effect of CD5 antibody on B cells from patients with rheumatoid arthritis.CD5抗体对类风湿性关节炎患者B细胞的刺激作用。
Clin Immunol Immunopathol. 1988 Nov;49(2):223-30. doi: 10.1016/0090-1229(88)90112-2.
9
10
B-cell-tropic interleukins in murine systemic lupus erythematosus (SLE) 1.小鼠系统性红斑狼疮（SLE）中的B细胞嗜性白细胞介素1
Immunol Rev. 1984 Apr;78:159-83. doi: 10.1111/j.1600-065x.1984.tb00481.x.
引用本文的文献
1
2
Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.慢性淋巴细胞白血病 B 细胞正常细胞对应物：从功能角度得到的线索。
Front Immunol. 2018 Apr 4;9:683. doi: 10.3389/fimmu.2018.00683. eCollection 2018.
3
B lymphocytes and humoral immune responses in rheumatoid arthritis.类风湿关节炎中的B淋巴细胞与体液免疫反应
Clin Rheumatol. 1995 Sep;14 Suppl 2:14-8. doi: 10.1007/BF02215852.
4
CD5 expression on B cells may be an activation marker for secretion of anti-myelin antibodies in patients with polyneuropathy associated with monoclonal gammopathy.B细胞上CD5的表达可能是与单克隆丙种球蛋白病相关的多发性神经病患者抗髓鞘抗体分泌的一种激活标志物。
Clin Exp Immunol. 1995 Aug;101(2):346-50. doi: 10.1111/j.1365-2249.1995.tb08362.x.
5
Autoantibodies and antibacterial antibodies: from both sides now.自身抗体和抗菌抗体：现在从两方面来看。
Ann Rheum Dis. 1990 Dec;49(12):961-5. doi: 10.1136/ard.49.12.961.
6
Effect of gold therapy on CD5+ B-cells and TCR gamma delta+ T-cells in patients with rheumatoid arthritis.
Rheumatol Int. 1991;11(4-5):175-8. doi: 10.1007/BF00332557.
本文引用的文献
1
DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.类风湿关节炎的诊断标准：美国风湿病协会委员会1958年修订版。
Ann Rheum Dis. 1959 Mar;18(1):49-51; French transl 51-2; Spanish transl 52-3.
2
[Diagnosis of chronic evolutive polyarthritis by agglutination of sensitized human red cells].[通过致敏人红细胞凝集诊断慢性进行性多关节炎]
Ann Inst Pasteur (Paris). 1958 May;94(5):659-62.
3
4
Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.罕见的正常B淋巴细胞表现出B细胞慢性淋巴细胞白血病的特征。
J Exp Med. 1982 Feb 1;155(2):623-8. doi: 10.1084/jem.155.2.623.
5
6
Properties of monoclonal antibodies to human immunoglobulin kappa and lambda chains.抗人免疫球蛋白κ和λ链单克隆抗体的特性
Immunology. 1981 Apr;42(4):649-59.
7
Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.Ly-1 B细胞：分泌IgM自身抗体的功能独特的淋巴细胞。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2494-8. doi: 10.1073/pnas.81.8.2494.
8
Evidence for B cell activation in patients with active rheumatoid arthritis.活动性类风湿关节炎患者B细胞活化的证据。
Clin Exp Immunol. 1984 Jan;55(1):91-8.
9
Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man.区分抑制/细胞毒性和辅助性T淋巴细胞亚群的膜结构抗体可阻断人类的混合淋巴细胞反应。
J Exp Med. 1981 Jul 1;154(1):193-8. doi: 10.1084/jem.154.1.193.
Zotero 插件