Department of Biological Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Integrated Mathematical Oncology Department, Moffitt Cancer Center, Tampa, Florida.
Cancer Res. 2019 May 1;79(9):2107-2110. doi: 10.1158/0008-5472.CAN-18-3937. Epub 2019 Apr 24.
While often described as a "disease of the genes," cancer is, in fact, a complex dynamic system in which evolving cells both affect and are affected by the physical properties of their environment. About 10 years ago, after a number of multidisciplinary workshops and meetings, the NCI leadership embarked on a bold program to systematically integrate physical sciences into cancer biology and treatment through formation of the Physical Sciences-Oncology Network (PS-ON). Here, we highlight key areas in which the two disciplines have been successfully integrated and lessons learned from the first decade of the PS-ON experiment.
虽然通常被描述为“基因疾病”，但癌症实际上是一个复杂的动态系统，其中不断进化的细胞既会影响也会受到其环境物理特性的影响。大约 10 年前，在多次多学科研讨会和会议之后，NCI 领导层开始了一项大胆的计划，通过组建物理科学-肿瘤学网络（PS-ON），系统地将物理科学纳入癌症生物学和治疗中。在这里，我们重点介绍了这两个学科成功整合的关键领域，以及 PS-ON 实验的第一个十年所吸取的经验教训。
