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斐济共和国结核病控制战略规划

Strategic Planning for Tuberculosis Control in the Republic of Fiji.

作者信息

Ragonnet Romain, Underwood Frank, Doan Tan, Rafai Eric, Trauer James, McBryde Emma

机构信息

Department of Medicine, the University of Melbourne and Department of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia.

Ministry of Health and Medical Services, Suva, Fiji.

出版信息

Trop Med Infect Dis. 2019 Apr 24;4(2):71. doi: 10.3390/tropicalmed4020071.

DOI:10.3390/tropicalmed4020071
PMID:31022901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6631049/
Abstract

The tuberculosis (TB) health burden in Fiji has been declining in recent years, although challenges remain in improving control of the diabetes co-epidemic and achieving adequate case detection across the widely dispersed archipelago. We applied a mathematical model of TB transmission to the TB epidemic in Fiji that captured the historical reality over several decades, including age stratification, diabetes, varying disease manifestations, and incorrect diagnoses. Next, we simulated six intervention scenarios that are under consideration by the Fiji National Tuberculosis Program. Our findings show that the interventions were able to achieve only modest improvements in disease burden, with awareness raising being the most effective intervention to reduce TB incidence, and treatment support yielding the highest impact on mortality. These improvements would fall far short of the ambitious targets that have been set by the country, and could easily be derailed by moderate increases in the diabetes burden. Furthermore, the effectiveness of the interventions was limited by the extensive pool of latent TB infection, because the programs were directed at only active cases, and thus were unlikely to achieve the desired reductions in burden. Therefore, it is essential to address the co-epidemic of diabetes and treat people with latent TB infection.

摘要

近年来,斐济的结核病健康负担一直在下降,不过在改善糖尿病合并流行情况的控制以及在这个广泛分布的群岛上实现足够的病例发现方面,仍然存在挑战。我们将结核病传播的数学模型应用于斐济的结核病流行情况,该模型捕捉了几十年的历史现实,包括年龄分层、糖尿病、不同的疾病表现以及错误诊断。接下来,我们模拟了斐济国家结核病规划正在考虑的六种干预方案。我们的研究结果表明,这些干预措施仅能在疾病负担方面取得适度改善,提高认识是降低结核病发病率最有效的干预措施,而治疗支持对死亡率的影响最大。这些改善远远达不到该国设定的宏伟目标,而且糖尿病负担的适度增加很容易使这些目标落空。此外,干预措施的有效性受到大量潜伏性结核感染人群的限制,因为这些规划仅针对活动性病例,因此不太可能实现预期的负担减轻。因此,应对糖尿病合并流行情况并治疗潜伏性结核感染人群至关重要。

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