The Norfolk Smell & Taste Clinic, James Paget University Hospital NHS Foundation Trust, Norfolk, UK.
Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado.
Clin Otolaryngol. 2019 Sep;44(5):715-728. doi: 10.1111/coa.13351. Epub 2019 Jun 17.
To adapt the existing German language olfactory disorders questionnaire for use with English-speaking patients. To validate the adapted version for routine clinical use.
The translated version of the original German questionnaire was revised with a patient and a clinician to reflect British language and culture. Patients attending an olfactory dysfunction clinic were recruited to perform the adapted questionnaire on two occasions at least 1 month apart. Additional online participants completed the questionnaire via the charity Fifth Sense.
Retest reliability of the English olfactory disorders questionnaire (eODQ) in affected patients including potential for redundancy in any of the included questions. Correlation of eODQ scores with Sniffin' Sticks scores.
Eighty-seven patients reporting olfactory dysfunction were recruited and had a mean age of 48 with 35% of them being male; 50 datasets were available for analysis. A total of 957 members of the charity entered responses into the online questionnaire; 699 responses could be scored with participants' mean age of 55 years and with 69% reporting as female. The eODQ score and Sniffin' Sticks threshold, discrimination and identification score at timepoint 1 were correlated to assess for concurrent validity, (r = -0.15, P = 0.17) and showed no significant correlation. Female participants had a significantly higher mean total eODQ score than men, 55.75 compared to 52.28 (P = 0.001). The average score was 54.7 (SD 13.5) with a range from 26 to 87. The internal consistency of the questionnaire was good with a Cronbach's alpha of 0.90 (confidence intervals 0.89, 0.91).
The results of this study support the use of the eODQ in a native English-speaking population and highlight the different distinctions between "objective" testing of olfaction with the Sniffin' Sticks test, and the patient reported impact of olfactory dysfunction on daily life. These two types of assessment can be easily administered in an outpatient setting and used in the assessment and management of olfactory dysfunction.
将现有的德语嗅觉障碍问卷改编为英文版，供英语患者使用。验证改编版在常规临床应用中的有效性。
对原始德语问卷的翻译版本进行修订，使其反映英国的语言和文化。招募在嗅觉功能障碍诊所就诊的患者，要求他们至少在两次就诊时使用改编后的问卷，两次就诊时间间隔至少 1 个月。慈善机构“第五感”的额外在线参与者通过在线方式完成问卷。
受影响患者的英语嗅觉障碍问卷（eODQ）重测信度，包括问卷中任何问题的冗余性。eODQ 评分与 Sniffin' Sticks 评分的相关性。
共招募了 87 名报告有嗅觉障碍的患者，平均年龄为 48 岁，其中 35%为男性；可分析的数据集共 50 个。慈善机构的 957 名成员在线回答了问卷；699 份答卷可评分，参与者的平均年龄为 55 岁，其中 69%为女性。评估同时效度时，第 1 时间点的 eODQ 评分和 Sniffin' Sticks 阈值、辨别和识别评分呈负相关（r=-0.15，P=0.17），且无显著相关性。女性患者的 eODQ 总分明显高于男性，分别为 55.75 和 52.28（P=0.001）。平均得分 54.7（标准差 13.5），得分范围为 26 到 87。问卷的内部一致性良好，克朗巴赫 α系数为 0.90（置信区间为 0.89，0.91）。
本研究结果支持在英语母语人群中使用 eODQ，并强调了 Sniffin' Sticks 测试“客观”嗅觉测试与患者报告的嗅觉障碍对日常生活影响之间的差异。这两种类型的评估可在门诊环境中轻松进行，并可用于嗅觉障碍的评估和管理。
