Federico Cinzia, Sacco Antonio, Belotti Angelo, Ribolla Rossella, Cancelli Valeria, Giacomini Arianna, Ronca Roberto, Chiarini Marco, Imberti Luisa, Marini Mirella, Rossi Giuseppe, Presta Marco, Paiva Bruno, Roccaro Aldo M
Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
CREA Laboratory, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Noncoding RNA. 2019 May 2;5(2):37. doi: 10.3390/ncrna5020037.
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone marrow infiltration of clonal plasma cells. The recent literature has clearly demonstrated clonal heterogeneity in terms of both the genomic and transcriptomic signature of the tumor. Of note, novel studies have also highlighted the importance of the functional cross-talk between the tumor clone and the surrounding bone marrow milieu, as a relevant player of MM pathogenesis. These findings have certainly enhanced our understanding of the underlying mechanisms supporting MM pathogenesis and disease progression. Within the specific field of small non-coding RNA-research, recent studies have provided evidence for considering microRNAs as a crucial regulator of MM biology and, in this context, circulating microRNAs have been shown to potentially contribute to prognostic stratification of MM patients. The present review will summarize the most recent studies within the specific topic of microRNAs and circulating microRNAs in MM.
多发性骨髓瘤（MM）是一种浆细胞发育异常疾病，其特征为克隆性浆细胞浸润骨髓。最近的文献清楚地表明，在肿瘤的基因组和转录组特征方面存在克隆异质性。值得注意的是，新的研究还强调了肿瘤克隆与周围骨髓微环境之间功能相互作用的重要性，这是MM发病机制的一个相关因素。这些发现无疑加深了我们对支持MM发病机制和疾病进展的潜在机制的理解。在小非编码RNA研究的特定领域，最近的研究提供了证据，表明微小RNA是MM生物学的关键调节因子，在此背景下，循环微小RNA已被证明可能有助于MM患者的预后分层。本综述将总结MM中微小RNA和循环微小RNA这一特定主题的最新研究。
