Gleicher N, el-Roeiy A, Confino E, Friberg J
Obstet Gynecol. 1987 Jul;70(1):115-22.
Among 59 laparoscopically staged endometriosis patients, 28.8% tested positive for antinuclear antibody. Of 44 patients, 45.5% were lupus anticoagulant positive (greater than 1.3) and 20.5% were within a borderline range (1.2-1.3). Antinuclear antibody positivity was inversely related to stage of disease (P = .009); lupus anticoagulant positivity exhibited a similar trend, but did not reach statistical significance. Of 31 endometriosis patients, 64.5% exhibited immunoglobulin G (IgG) autoantibodies and 45.2% demonstrated IgM autoantibodies to at least one of 16 antigens investigated. Among IgG autoantibodies, those to phospholipids were most frequently detected, followed in order of frequency by antibodies to histones and nucleotides. The incidence of IgM autoantibodies was inverted, with antinucleotides appearing most frequently and antiphospholipids least frequently. A strong correlation was noted between the presence of lupus anticoagulant and antinuclear antibody with both IgG and IgM autoantibodies. These observations suggest that endometriosis is associated with abnormal polyclonal B cell activation, a classic characteristic of autoimmune disease. This contention is further supported in that immunoglobulin levels (particularly IgG) are elevated in patients with endometriosis, and more so in lupus anticoagulant-positive than lupus anticoagulant-negative endometriosis patients (P = .021).
在59例经腹腔镜分期的子宫内膜异位症患者中，28.8%的患者抗核抗体检测呈阳性。在44例患者中，45.5%的患者狼疮抗凝物呈阳性（大于1.3），20.5%处于临界范围（1.2 - 1.3）。抗核抗体阳性与疾病分期呈负相关（P = .009）；狼疮抗凝物阳性呈现类似趋势，但未达到统计学显著性。在31例子宫内膜异位症患者中，64.5%的患者表现出免疫球蛋白G（IgG）自身抗体，45.2%的患者针对所研究的16种抗原中的至少一种表现出IgM自身抗体。在IgG自身抗体中，磷脂抗体最常被检测到，其次是组蛋白和核苷酸抗体，频率依次递减。IgM自身抗体的发生率则相反，抗核苷酸抗体出现频率最高，抗磷脂抗体出现频率最低。狼疮抗凝物与抗核抗体以及IgG和IgM自身抗体之间存在强烈相关性。这些观察结果表明，子宫内膜异位症与异常的多克隆B细胞活化有关，这是自身免疫性疾病的一个典型特征。子宫内膜异位症患者免疫球蛋白水平（尤其是IgG）升高，狼疮抗凝物阳性的子宫内膜异位症患者比狼疮抗凝物阴性的患者升高更明显（P = .021），这进一步支持了这一论点。
