Beijing Laboratory of Biomedical Materials , Beijing University of Chemical Technology , Beijing 100029 , P. R. China.
Department of Gastroenterology , China-Japan Friendship Hospital , Beijing 100029 , P. R. China.
ACS Appl Mater Interfaces. 2019 Jul 10;11(27):23848-23857. doi: 10.1021/acsami.9b04956. Epub 2019 Jun 27.
Thermal release of zeolite is conducive in hemostasis, but losing control will cause serious burns. How to balance the advantages and disadvantages is a challenge. Herein, a zeolite/cross-linked graphene sponge (Z-CGS) was design to break through this challenge. The CGS managed the heat release of zeolite by thermal conduction of graphene. Infrared thermal imager demonstrated the mild exothermic process and good thermal conductivity of the optimized Z-CGS. It controlled wound temperature below 42 °C effectively, as compared to 70 °C of naked zeolite. Blood clotting index further confirmed the contribution of thermal stimulation in Z-CGS. On the synergy of thermal and charge stimulations of zeolite, as well as physical adsorption of CGS, Z-CGS achieved outstanding hemostatic performance. Bleeding was stopped within 69 s in rat artery injury model, faster than that of the Quikclot Combat Gauze. Additionally, cytotoxicity assay and pathological analysis highlighted its biocompatibility. Z-CGS, therefore, was an outstanding composite of combining advantages of zeolite and graphene, while getting rid of the shortcomings of the basic unit. The thermal conductibility of graphene renews an avenue for the safe and highly efficient use of zeolite in hemostasis.
沸石的热释放有利于止血，但失去控制会导致严重烧伤。如何平衡利弊是一个挑战。在这里，设计了沸石/交联石墨烯海绵（Z-CGS）来突破这一挑战。CGS 通过石墨烯的热传导来控制沸石的热释放。红外热像仪证明了优化后的 Z-CGS 具有温和的放热过程和良好的导热性。与裸露的沸石相比，它可以将伤口温度有效控制在 42°C 以下。凝血指数进一步证实了热刺激对 Z-CGS 的贡献。由于沸石的热和电荷刺激以及 CGS 的物理吸附的协同作用，Z-CGS 实现了出色的止血性能。在大鼠动脉损伤模型中，出血在 69 秒内停止，比 Quikclot Combat Gauze 更快。此外，细胞毒性试验和病理分析突出了其生物相容性。因此，Z-CGS 是沸石和石墨烯优势结合的优秀复合材料，同时摆脱了基本单元的缺点。石墨烯的导热性为沸石在止血中的安全高效使用开辟了新途径。
