Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Mar Drugs. 2012 Mar;10(3):668-676. doi: 10.3390/md10030668. Epub 2012 Mar 22.
Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.
从海洋来源的细菌 Streptomyces lusitanus 的废弃发酵液中分离得到两种新的安密霉素 A 类似物，安密霉素 B1 和 B2（1-2）。根据光谱分析和化学方法确定了 1 和 2 的结构。对分离得到的化合物进行了抗菌活性测试。化合物 1 对枯草芽孢杆菌、金黄色葡萄球菌和洛特卡氏菌 Hongkongensis 没有活性。化合物 2 对金黄色葡萄球菌和洛特卡氏菌 Hongkongensis 具有抗菌活性，MIC 值分别为 32.0 和 8.0 μg/mL。
