癌症与生物钟。
Cancer and the Circadian Clock.
机构信息
Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
出版信息
Cancer Res. 2019 Aug 1;79(15):3806-3814. doi: 10.1158/0008-5472.CAN-19-0566. Epub 2019 Jul 12.
Abstract
The circadian clock is a master regulator of mammalian physiology, regulating daily oscillations of crucial biological processes and behaviors. Notably, circadian disruption has recently been identified as an independent risk factor for cancer and classified as a carcinogen. As such, it is imperative to discern the underpinning mechanisms by which circadian disruption alters cancer risk. Emergent data, reviewed herein, demonstrate that circadian regulatory functions play critical roles in several hallmarks of cancer, including control of cell proliferation, cell death, DNA repair, and metabolic alteration. Developing a deeper understanding of circadian-cancer regulation cross-talk holds promise for developing new strategies for cancer interception, prevention, and management.
摘要
生物钟是哺乳动物生理学的主要调节者，调节着关键生物过程和行为的日常波动。值得注意的是，最近发现生物钟紊乱是癌症的一个独立风险因素，并被归类为一种致癌物质。因此，必须弄清生物钟紊乱改变癌症风险的潜在机制。本文综述了新出现的数据表明，生物钟的调节功能在癌症的几个特征中起着关键作用，包括控制细胞增殖、细胞死亡、DNA 修复和代谢改变。深入了解生物钟与癌症调控的相互作用有望为癌症的干预、预防和管理制定新的策略。
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