Earnest M P, Heaton R K, Wilkinson W E, Manke W F
Neurology. 1979 Aug;29(8):1138-43. doi: 10.1212/wnl.29.8.1138.
Fifty-nine subjects over age 60 had a computerized tomography (CT) scan and completed four neuropsychological tests. Measurements of ventricular size and sulcal enlargement were compared to test performance. Performance of the elderly subjects was also compared to that of subjects aged 16 to 40 years. Subjects over 60 years of age had significantly more brain atrophy and more impaired test performance than younger subjects. Subjects aged 80 to 99 had more atrophy and impaired performance than those 60 to 79 years. Our results suggest that, with aging, the brain atrophies and loses its abilities as measured by neuropsychological testing. However, CT evidence of atrophy only weakly predicts impaired mental function independently of age.
59名60岁以上的受试者接受了计算机断层扫描（CT），并完成了四项神经心理学测试。将脑室大小和脑沟增宽的测量结果与测试表现进行比较。还将老年受试者的表现与16至40岁受试者的表现进行了比较。60岁以上的受试者比年轻受试者有明显更多的脑萎缩和更差的测试表现。80至99岁的受试者比60至79岁的受试者有更多的萎缩和更差的表现。我们的结果表明，随着年龄的增长，大脑会萎缩，并在神经心理学测试中表现出能力丧失。然而，萎缩的CT证据仅在独立于年龄的情况下对心理功能受损有较弱的预测作用。
