Ahi Zehra Betul, Renkler Nergis Zeynep, Gul Seker Mine, Tuzlakoglu Kadriye
Yalova University, Department of Polymer Engineering, Yalova 77200, Turkey.
Gebze Technical University, Department of Molecular Biology and Genetics, Kocaeli, Turkey.
Int J Biomater. 2019 Aug 14;2019:7932470. doi: 10.1155/2019/7932470. eCollection 2019.
Biodegradable composite membranes containing propolis were produced from PCL/PLLA blends using a simple and low-cost solvent casting method, and subsequently their physicochemical, mechanical, and antibacterial properties were characterized. SEM analysis revealed that the addition of propolis has created honeycomb-like structures on the film surfaces. The flexibility of the films increased in the presence of propolis, which may provide ease of use during application. Propolis disrupted the organized structure of both polymers at the molecular level and caused decreases in the melting points. The films with propolis showed faster degradation in physiological conditions due to this molecular disruption. Moreover, the PLLA/PCL/propolis composite films exhibited remarkable antibacterial activities against . Collectively, the data suggest that the produced films might be used as an alternative to exiting barrier membranes in guided tissue regeneration.
采用简单且低成本的溶剂浇铸法，由聚己内酯（PCL）/聚乳酸（PLLA）共混物制备了含蜂胶的可生物降解复合膜，随后对其物理化学、机械和抗菌性能进行了表征。扫描电子显微镜（SEM）分析表明，添加蜂胶后在膜表面形成了蜂窝状结构。在蜂胶存在的情况下，膜的柔韧性增加，这可能使应用过程更加便捷。蜂胶在分子水平上破坏了两种聚合物的有序结构，并导致熔点降低。由于这种分子破坏，含蜂胶的膜在生理条件下显示出更快的降解速度。此外，PLLA/PCL/蜂胶复合膜对……表现出显著的抗菌活性。总体而言，数据表明所制备的膜可作为引导组织再生中现有屏障膜的替代品。
