Yang Zhen, Dai Yunlu, Shan Lingling, Shen Zheyu, Wang Zhantong, Yung Bryant C, Jacobson Orit, Liu Yijing, Tang Wei, Wang Sheng, Lin Lisen, Niu Gang, Huang Pintong, Chen Xiaoyuan
Department of Ultrasound in Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine. No. 88 Jiefang Road, Hangzhou.310009, P. R. China.
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.
Nanoscale Horiz. 2019 Mar 1;4(2):426-433. doi: 10.1039/C8NH00307F. Epub 2018 Oct 18.
A Pt prodrug polyphenol and gadolinium ion loaded cancer theranostics nanoplatform based on mild acidic pH and thermal sensitive polymer was designed for photoacoustic (PA)/ magnetic resonance(MR)/ positron emission tomography (PET) multimodal imaging-guided chemo-photothermal combination therapy. The Pt drug release can be controlled by tumour-specific acidic pH and heat generated by external NIR irradiation. The nanoparticles were stable under normal physiological environment and released the drug under tumour acidic pH and NIR laser irradiation, which can reduce the side effect of drug to normal organs. Moreover, the MR signal can be significantly enhanced (~3-fold increase in T1 relaxivity) under the acidic tumour microenvironment, which is favorable for cancer diagnosis. The nanoparticles exhibited excellent tumour accumulation and led to complete tumour eradication with low power NIR laser irradiation. This promising approach provides a new avenue for imaging-guided combination therapy.
基于温和酸性pH和热敏聚合物设计了一种负载铂前药多酚和钆离子的癌症诊疗纳米平台，用于光声（PA）/磁共振（MR）/正电子发射断层扫描（PET）多模态成像引导的化学-光热联合治疗。铂药物的释放可由肿瘤特异性酸性pH和外部近红外（NIR）照射产生的热量控制。纳米颗粒在正常生理环境下稳定，在肿瘤酸性pH和NIR激光照射下释放药物，这可以减少药物对正常器官的副作用。此外，在酸性肿瘤微环境下，MR信号可显著增强（纵向弛豫率增加约3倍），这有利于癌症诊断。纳米颗粒表现出优异的肿瘤蓄积性，并通过低功率NIR激光照射实现肿瘤完全根除。这种有前景的方法为成像引导的联合治疗提供了一条新途径。
