Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
Clinics (Sao Paulo). 2019 Sep 26;74:e1017. doi: 10.6061/clinics/2019/e1017. eCollection 2019.
Psychiatric depression disorder is common in patients with systolic congestive heart failure (HF), and both conditions share underlying pathophysiological mechanisms. The incidence rate of depression disorder has clearly increased with the increase in HF manifestations in recent decades. Depression disorder is considered an independent predisposing factor for hospitalization, disturbed functional performance, and high rates of morbidity and mortality in HF patients. This randomized controlled study was designed to examine the impacts of low- to moderate-intensity aerobic exercise training on depression status in patients with systolic congestive HF.
A total of 46 systolic congestive HF patients with depression (40-60 years of age) were randomized to receive twelve weeks of mild- to moderate-intensity aerobic exercise plus standard medical treatment (exercise group) or standard medical treatment without any exercise intervention (control group). Depression status was examined using the validated Patient Health Questionnaire-9 (PHQ9) pre- and post-intervention at the end of the study program.
No significant differences were observed between the exercise and control groups in demographic data or clinical characteristics (p>0.05). Both study groups showed a significant reduction in depression status at the end of the 12-week intervention (p<0.05). The comparison between the mean values of the depression scores showed significant differences between the two groups after 6 and 12 weeks of the intervention, indicating a greater reduction in depression scores in the exercise group than in the control group (p<0.05).
Twelve weeks of a low- to moderate-intensity aerobic exercise program was safe and effective for reducing depression severity in patients with systolic congestive HF. Low- to moderate-intensity aerobic training should be recommended for cardiac patients, particularly those with HF-related depression.
精神科抑郁症在收缩性充血性心力衰竭（HF）患者中很常见，这两种疾病都有潜在的病理生理机制。近几十年来，随着 HF 表现的增加，抑郁症的发病率明显增加。抑郁症被认为是 HF 患者住院、功能障碍和高发病率和死亡率的独立诱发因素。这项随机对照研究旨在探讨低至中等强度的有氧运动训练对收缩性充血性 HF 患者抑郁状态的影响。
共 46 名患有抑郁症的收缩性充血性 HF 患者（40-60 岁）随机分为接受 12 周低至中等强度有氧运动加标准药物治疗（运动组）或不进行任何运动干预的标准药物治疗（对照组）。在研究项目结束时，使用经过验证的患者健康问卷-9（PHQ9）在干预前后检查抑郁状态。
运动组和对照组在人口统计学数据或临床特征方面无显著差异（p>0.05）。两组在 12 周干预结束时均显示抑郁状态显著减轻（p<0.05）。比较两组抑郁评分的平均值，表明干预 6 周和 12 周后两组之间存在显著差异，表明运动组的抑郁评分降低幅度大于对照组（p<0.05）。
12 周的低至中等强度有氧运动方案对减轻收缩性充血性 HF 患者的抑郁严重程度是安全有效的。低至中等强度的有氧运动训练应推荐给心脏病患者，特别是那些患有 HF 相关抑郁症的患者。
