Bakre Sulaimon A, Al-Farra Tariq S, Al-Farra Sherif
Resident at Carilion Clinic, Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA, 24016, USA.
Resident at Johns Hopkins Hospital, 1800 Orleans St, Baltimore, MD, 21287, USA.
Respir Med Case Rep. 2019 Sep 24;28:100935. doi: 10.1016/j.rmcr.2019.100935. eCollection 2019.
The prevalence of e-cigarette usage has increased in non-smokers and those who are planning to quit smoking since introduced in 2003. Although the potential long term adverse effects have not been studied in humans, there have been studies showing that e-cigarette vapor causes release of proinflammatory cytokines leading to cytotoxic damage to alveolar epithelial cells, increase in the release of fibroblast growth factor (FGF) in the alveolar epithelial cells which leads to fibroblastic proliferation, and increased risk of staphylococcus aureus and viral infections which are implicated in the pathogenesis of diffuse alveolar damage. We describe a case of a 47-year-old woman who was diagnosed with histologically confirmed diffuse alveolar damage (DAD). She had no significant medical history and she had been smoking e-cigarettes for 3 years prior to presentation. This case report describes the potential association between e-cigarettes and diffuse alveolar damage while making reference to relevant associated studies.
自2003年电子烟问世以来，非吸烟者及打算戒烟者中电子烟的使用 prevalence有所增加。尽管尚未在人体中研究其潜在的长期不良反应，但已有研究表明，电子烟烟雾会导致促炎细胞因子释放，进而对肺泡上皮细胞造成细胞毒性损伤，使肺泡上皮细胞中促纤维细胞生长因子（FGF）的释放增加，导致成纤维细胞增殖，并且增加金黄色葡萄球菌和病毒感染的风险，而这些感染与弥漫性肺泡损伤的发病机制有关。我们描述了一例47岁女性患者，经组织学确诊为弥漫性肺泡损伤（DAD）。她没有明显的病史，在就诊前已吸食电子烟3年。本病例报告在参考相关关联研究的同时，描述了电子烟与弥漫性肺泡损伤之间的潜在关联。
