Antimicrobial potential of endophytic fungi from .

The purpose of the present study was to discover antimicrobial endophytic fungi from Three fungal endophytes with antibacterial activity were isolated and determined as sp. HQ-1, sp. HQ-7 and sp. HQ-9 based on the neighbor-joining phylogenetic tree. sp. HQ-1 showed the best antibiotic potential and was thus selected for large-scale fermentation. Bioactivity-directed separation of ME fermentation of strain HQ-1 led to the discovery of three compounds, which were identified as differanisole A (), 2,6-dichloro-4-propylphenol () and 4,5-dimethylresorcinol (), from the HR-ESI-MS and NMR data analysis. All three compounds exhibited moderate antibacterial activity against , , and methicillin-resistant , with MIC values ranging from 16 to 128 μg/mL. Compounds and also displayed promising antifungal activity against with IC values of less than 16 and 32 μg/mL, respectively, which were comparable to that of actidione (8 μg/mL). The findings of the present study suggest that the endophytic fungi from have the potential to be used as bactericides and fungicides.