Chen Yanwei, Chen Xuechen, Yu Haixin, Zhou Haibo, Xu Shu
Infection Control Department of Shenzhen Hospital of University of Chinese Academy of Sciences, Shenzhen, People's Republic of China.
Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
Onco Targets Ther. 2019 Dec 18;12:11131-11144. doi: 10.2147/OTT.S230262. eCollection 2019.
Emerging evidence has shown the potential of oral microbiota as a noninvasive diagnostic tool in gastrointestinal (GI) cancer. PubMed, Web of Science, and Embase were systematically searched for eligible studies published until May 31, 2019. Of the 17 included studies published between 2011 and 2019, five kinds of GI cancer, including colorectal cancer (n=6), pancreatic cancer (n=5), gastric cancer (n=4), esophageal cancer (n=2) and liver cancer (n=1), were reported. Generally, the diagnostic performance of the multi-bacteria model for GI cancer was strong with the best area under the receiver operator characteristic curve (AUC) exceeding 0.90, but only one study had a validation phase. Pathogens involved in periodontal disease, such as and , were linked to various kinds of GI cancer. Besides, more oral bacteria significantly differed between cases with upper digestive cancer and healthy controls when compared to colorectal cancer (the most common form of lower digestive cancer), probably indicating a different mechanism due to anatomical and physiological differences in the digestive tract. Oral microbiota changes were associated with risk of various kinds of GI cancer, which could be considered as a potential tool for early prediction and prevention of GI cancer, but validation based on a large population, reproducible protocols for oral microbiota research and oral-gut microbiota transmission patterns are required to be resolved in further studies.
新出现的证据表明，口腔微生物群作为胃肠道（GI）癌的一种非侵入性诊断工具具有潜力。我们系统检索了PubMed、科学网和Embase，以查找截至2019年5月31日发表的符合条件的研究。在2011年至2019年发表的17项纳入研究中，报告了五种胃肠道癌症，包括结肠癌（n = 6）、胰腺癌（n = 5）、胃癌（n = 4）、食管癌（n = 2）和肝癌（n = 1）。总体而言，胃肠道癌多细菌模型的诊断性能较强，最佳受试者操作特征曲线下面积（AUC）超过0.90，但只有一项研究有验证阶段。牙周病相关病原体，如 和 ，与各种胃肠道癌有关。此外，与结肠癌（下消化道最常见的癌症形式）相比，上消化道癌患者与健康对照之间的口腔细菌差异更为显著，这可能表明由于消化道的解剖和生理差异导致了不同的机制。口腔微生物群的变化与各种胃肠道癌的风险相关，这可被视为早期预测和预防胃肠道癌的潜在工具，但在进一步研究中需要解决基于大量人群的验证、口腔微生物群研究的可重复方案以及口腔-肠道微生物群传播模式等问题。
