Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid & CIBER-BBN, Madrid, Spain.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sci Rep. 2020 Jan 15;10(1):338. doi: 10.1038/s41598-019-56989-5.
Subtle interstitial changes in the lung parenchyma of smokers, known as Interstitial Lung Abnormalities (ILA), have been associated with clinical outcomes, including mortality, even in the absence of Interstitial Lung Disease (ILD). Although several methods have been proposed for the automatic identification of more advanced Interstitial Lung Disease (ILD) patterns, few have tackled ILA, which likely precedes the development ILD in some cases. In this context, we propose a novel methodology for automated identification and classification of ILA patterns in computed tomography (CT) images. The proposed method is an ensemble of deep convolutional neural networks (CNNs) that detect more discriminative features by incorporating two, two-and-a-half and three- dimensional architectures, thereby enabling more accurate classification. This technique is implemented by first training each individual CNN, and then combining its output responses to form the overall ensemble output. To train and test the system we used 37424 radiographic tissue samples corresponding to eight different parenchymal feature classes from 208 CT scans. The resulting ensemble performance including an average sensitivity of 91,41% and average specificity of 98,18% suggests it is potentially a viable method to identify radiographic patterns that precede the development of ILD.
吸烟者肺部间质的细微变化,称为肺间质异常(ILA),与临床结果相关,包括死亡率,即使在没有间质性肺病(ILD)的情况下也是如此。尽管已经提出了几种用于自动识别更高级间质性肺病(ILD)模式的方法,但很少有方法解决 ILA 问题,在某些情况下,ILA 可能先于 ILD 的发展。在这种情况下,我们提出了一种用于计算机断层扫描(CT)图像中 ILA 模式自动识别和分类的新方法。所提出的方法是一个深度卷积神经网络(CNN)的集合,通过合并两个、两个半和三个维度的架构来检测更具鉴别力的特征,从而实现更准确的分类。该技术通过首先训练每个单独的 CNN,然后结合其输出响应来形成整体集合输出来实现。为了训练和测试系统,我们使用了 37424 个放射组织样本,这些样本对应于 208 次 CT 扫描中的八个不同的实质特征类。该集合的性能包括平均敏感性为 91.41%和平均特异性为 98.18%,这表明它可能是一种可行的方法,可用于识别先于 ILD 发展的放射学模式。