Yilma T, Hsu D, Jones L, Owens S, Grubman M, Mebus C, Yamanaka M, Dale B
Department of Veterinary Microbiology and Immunology, University of California, Davis 95616.
Science. 1988 Nov 18;242(4881):1058-61. doi: 10.1126/science.3194758.
Rinderpest is a highly contagious ruminant viral disease manifested by a rapid course and greater than 90% mortality. Infectious vaccinia virus recombinants were constructed that express either the hemagglutinin or the fusion gene of rinderpest virus. All cattle vaccinated with either recombinant or with the combined recombinants produced neutralizing antibodies against rinderpest virus and were protected against the disease when challenged with more than 1000 times the lethal dose of the virus.
牛瘟是一种高度传染性的反刍动物病毒性疾病，病程迅速，死亡率超过90%。构建了表达牛瘟病毒血凝素或融合基因的传染性痘苗病毒重组体。用任何一种重组体或联合重组体接种的所有牛都产生了针对牛瘟病毒的中和抗体，并且在受到超过致死剂量1000倍的病毒攻击时受到了疾病保护。
