Huang Haiqin, Qi Xiaole, Chen Yanhua, Wu Zhenghong
Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Department of Pharmacy, Wuxi Children's Hospital, Wuxi 214000, PR China.
Saudi Pharm J. 2019 Nov;27(7):990-999. doi: 10.1016/j.jsps.2019.08.001. Epub 2019 Aug 5.
To date, a variety of delivery systems based on organic or inorganic materials have been investigated. Among them, hydrogels have become one of the most promising field in drug delivery system due to their unique properties. Temperature-sensitive hydrogels, which gelation at physiological temperature, gift the delivery system with excellent spatial and temporal control, and have a widely application in drug delivery, tissue engineering, imaging, and wound dressing. This review provides a brief overview on the concept and classification of temperature-sensitive hydrogels, and covers the application of temperature-sensitive gel systems in delivery of biotherapeutic molecules.
迄今为止，人们已经研究了多种基于有机或无机材料的递送系统。其中，水凝胶因其独特的性质，已成为药物递送系统中最有前景的领域之一。温敏水凝胶在生理温度下凝胶化，赋予递送系统出色的时空控制能力，在药物递送、组织工程、成像和伤口敷料等方面有广泛应用。本文综述简要概述了温敏水凝胶的概念和分类，并涵盖了温敏凝胶系统在生物治疗分子递送中的应用。
