一种由新型、高转移性且广泛宿主范围 IncA 质粒连接的产 VIM-1 碳青霉烯酶的多物种群预示着 VIM-1 的再次出现。
A Multispecies Cluster of VIM-1 Carbapenemase-Producing Linked by a Novel, Highly Conjugative, and Broad-Host-Range IncA Plasmid Forebodes the Reemergence of VIM-1.
机构信息
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
出版信息
Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.02435-19.
Abstract
In this study, we investigated VIM-1-producing , , , , and strains, isolated in 2019 during a period of active surveillance of carbapenem-resistant in a large university hospital in Italy. VIM-1-producing strains colonized the gut of patients, with up to three different VIM-1-positive bacterial species isolated from a single rectal swab, but also caused bloodstream infection in one colonized patient. In the multispecies cluster, was identified in a 5-gene cassette class 1 integron, associated with several genetic determinants, including the , , and (A) genes, located on a highly conjugative and broad-host-range IncA plasmid. The characteristics and origin of this IncA plasmid were studied.
摘要
在这项研究中，我们调查了 2019 年在意大利一家大型大学医院对碳青霉烯类耐药 进行积极监测期间分离出的产 VIM-1 的 、 、 、 和 株。产 VIM-1 的菌株定植在患者的肠道中，从单个直肠拭子中最多可分离出三种不同的产 VIM-1 阳性细菌，但也导致定植患者发生血流感染。在多菌种群中， 在一个 5 基因盒类 1 整合子中被鉴定，与几个遗传决定因素相关，包括 、 、 和 （A）基因，位于一个具有高转移性和广泛宿主范围的 IncA 质粒上。研究了这种 IncA 质粒的特性和来源。
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