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本文引用的文献

1
Wheel running behaviour in group-housed female mice indicates disturbed wellbeing due to DSS colitis.群居饲养的雌性小鼠的转轮行为表明其由于 DSS 结肠炎而出现不适。
Lab Anim. 2020 Feb;54(1):63-72. doi: 10.1177/0023677219879455. Epub 2019 Nov 1.
2
Behavioral and neural correlates of hide-and-seek in rats.大鼠捉迷藏行为及其神经基础。
Science. 2019 Sep 13;365(6458):1180-1183. doi: 10.1126/science.aax4705.
3
Environmental enrichment and mouse models: Current perspectives.环境富集与小鼠模型:当前观点
Animal Model Exp Med. 2018 Jul 28;1(2):82-90. doi: 10.1002/ame2.12015. eCollection 2018 Jun.
4
Effects of Cage Enrichment on Behavior, Welfare and Outcome Variability in Female Mice.笼内丰富环境对雌性小鼠行为、福利及结果变异性的影响
Front Behav Neurosci. 2018 Oct 26;12:232. doi: 10.3389/fnbeh.2018.00232. eCollection 2018.
5
Handling method alters the hedonic value of reward in laboratory mice.处理方法改变了实验室小鼠奖赏的享乐价值。
Sci Rep. 2018 Feb 5;8(1):2448. doi: 10.1038/s41598-018-20716-3.
6
Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research.重新思考3R策略:深入探究动物试验信息促进体内生物医学研究的透明度。
PLoS Biol. 2017 Dec 14;15(12):e2003217. doi: 10.1371/journal.pbio.2003217. eCollection 2017 Dec.
7
To Group or Not to Group? Good Practice for Housing Male Laboratory Mice.分组还是不分组?雄性实验小鼠饲养的良好做法。
Animals (Basel). 2017 Nov 24;7(12):88. doi: 10.3390/ani7120088.
8
Play and optimal welfare: Does play indicate the presence of positive affective states?玩耍与最佳福利:玩耍是否表明存在积极情感状态?
Behav Processes. 2018 Nov;156:3-15. doi: 10.1016/j.beproc.2017.11.011. Epub 2017 Nov 16.
9
Aggression in group-housed laboratory mice: why can't we solve the problem?群体饲养实验小鼠的攻击行为:我们为何无法解决这个问题?
Lab Anim (NY). 2017 Mar 22;46(4):157-161. doi: 10.1038/laban.1219.
10
Introducing Clicker Training as a Cognitive Enrichment for Laboratory Mice.引入点击训练作为实验小鼠的认知强化手段。
J Vis Exp. 2017 Mar 6(121):55415. doi: 10.3791/55415.

实验之外的动物福利推动因素。

Impulse for animal welfare outside the experiment.

作者信息

Lewejohann Lars, Schwabe Kerstin, Häger Christine, Jirkof Paulin

机构信息

German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany.

Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Freie Universität Berlin, Germany.

出版信息

Lab Anim. 2020 Apr;54(2):150-158. doi: 10.1177/0023677219891754. Epub 2020 Feb 12.

DOI:10.1177/0023677219891754
PMID:32050843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7160751/
Abstract

Animal welfare is a growing societal concern and the well-being of animals used for experimental purposes is under particular scrutiny. The vast majority of laboratory animals are mice living in small cages that do not offer very much variety. Moreover, the experimental procedure often takes very little time compared to the time these animals have been bred to the desired age or are being held available for animal experimentation. However, for the assessment of animal welfare, the time spent waiting for an experiment or the time spent after finishing an experiment has also to be taken into account. In addition to experimental animals, many additional animals (e.g. for breeding and maintenance of genetic lines, surplus animals) are related to animal experimentation and usually face similar living conditions. Therefore, in terms of improving the overall welfare of laboratory animals, there is not only a need for refinement of experimental conditions but especially for improving living conditions outside the experiment. The improvement of animal welfare thus depends to a large extent on the housing and maintenance conditions of all animals related to experimentation. Given the current state of animal welfare research there is indeed a great potential for improving the overall welfare of laboratory animals.

摘要

动物福利是社会日益关注的问题,用于实验目的的动物的福祉受到特别审查。绝大多数实验动物是生活在小笼子里的小鼠,笼子里的环境变化很少。此外,与这些动物被饲养到所需年龄或可供动物实验使用的时间相比,实验过程通常花费的时间很少。然而,对于动物福利的评估,等待实验的时间或实验结束后的时间也必须考虑在内。除了实验动物外,许多其他动物(例如用于繁殖和维持遗传品系的动物、多余的动物)也与动物实验相关,并且通常面临类似的生活条件。因此,就改善实验动物的整体福利而言,不仅需要优化实验条件,而且尤其需要改善实验之外的生活条件。动物福利的改善在很大程度上取决于与实验相关的所有动物的饲养和管理条件。鉴于动物福利研究的现状,改善实验动物的整体福利确实有很大潜力。