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药物及给药装置的3D打印

3D Printing of Pharmaceuticals and Drug Delivery Devices.

作者信息

Mathew Essyrose, Pitzanti Giulia, Larrañeta Eneko, Lamprou Dimitrios A

机构信息

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

Department of Life and Environmental Sciences (Unit of Drug Sciences), University of Cagliari, 09124 Cagliari, Italy.

出版信息

Pharmaceutics. 2020 Mar 15;12(3):266. doi: 10.3390/pharmaceutics12030266.

Abstract

The process of 3D printing (3DP) was patented in 1986; however, the research in the field of 3DP did not become popular until the last decade. There has been an increasing research into the areas of 3DP for medical applications for fabricating prosthetics, bioprinting and pharmaceutics. This novel method allows the manufacture of dosage forms on demand, with modifications in the geometry and size resulting in changes to the release and dosage behaviour of the product. 3DP will allow wider adoption of personalised medicine due to the diversity and simplicity to change the design and dosage of the products, allowing the devices to be designed specific to the individual with the ability to alternate the drugs added to the product. Personalisation also has the potential to decrease the common side effects associated with generic dosage forms. This Special Issue Editorial outlines the current innovative research surrounding the topic of 3DP, focusing on bioprinting and various types of 3DP on applications for drug delivery as well advantages and future directions in this field of research.

摘要

3D打印(3DP)工艺于1986年获得专利;然而,3DP领域的研究直到过去十年才开始流行起来。在用于制造假肢、生物打印和制药的医疗应用3DP领域,研究一直在增加。这种新颖的方法允许按需制造剂型,几何形状和尺寸的改变会导致产品释放和剂量行为的变化。由于产品设计和剂量的多样性和简单性,3DP将使个性化医疗得到更广泛的应用,使设备能够针对个体进行设计,并能够改变添加到产品中的药物。个性化还有可能减少与普通剂型相关的常见副作用。本期特刊社论概述了围绕3DP主题的当前创新性研究,重点是生物打印以及各种类型的3DP在药物递送应用方面的研究,以及该研究领域的优势和未来方向。

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