Nutrition Research Center, Student Research Committee, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, 5166614711, Iran.
BMC Res Notes. 2020 Apr 16;13(1):218. doi: 10.1186/s13104-020-05059-5.
This study aimed to examine the relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults. In this cross-sectional study, a total of 95 subjects aged > 20 years newly diagnosed with NAFLD were recruited. NAFLD was diagnosed using ultrasonography by a single expert radiologist in a fasting state.
The mean age of the patients was 49.27 (SD 9.7) years, with 53.68% males and 46.32% females. Most patients had grade I NAFLD (72.63%), 25.26% were grade II, and 2.11% were grade III on ultrasonography. With increasing severity of liver steatosis, there were statistically significant increases in mean body mass index (P = 0.001), serum triglycerides (P = 0.026), alanine aminotransferase (P < 0.001), aspartate aminotransferase (P < 0.001), and fasting blood sugar (P = 0.041), and there was a statistically significant decrease in mean serum high-density lipoprotein cholesterol (P = 0.011). However, no association was found between severity of liver steatosis and serum total cholesterol (P = 0.271), low-density lipoprotein cholesterol (P = 0.341), and alkaline phosphatase (P = 0.234). In conclusion, the severity of ultrasonographic liver steatosis was significantly associated with abnormal metabolic parameters.
本研究旨在伊朗成年人样本中检查肝脂肪变性严重程度与代谢参数之间的关系。在这项横断面研究中，共招募了 95 名年龄大于 20 岁新诊断为非酒精性脂肪性肝病的患者。通过一位经验丰富的放射科医生在空腹状态下使用超声检查诊断非酒精性脂肪性肝病。
患者的平均年龄为 49.27（SD 9.7）岁，男性占 53.68%，女性占 46.32%。大多数患者的超声检查结果为肝脂肪变性 I 级（72.63%），25.26%为 II 级，2.11%为 III 级。随着肝脂肪变性严重程度的增加，平均体重指数（P=0.001）、血清三酰甘油（P=0.026）、丙氨酸氨基转移酶（P<0.001）、天冬氨酸氨基转移酶（P<0.001）和空腹血糖（P=0.041）显著升高，而平均血清高密度脂蛋白胆固醇（P=0.011）显著降低。然而，肝脂肪变性严重程度与血清总胆固醇（P=0.271）、低密度脂蛋白胆固醇（P=0.341）和碱性磷酸酶（P=0.234）之间无关联。结论：超声肝脂肪变性的严重程度与异常代谢参数显著相关。
