Wang Jui-Hsing, He Guo-Cheng, Huang Yao-Ting, Liu Po-Yu
Division of Infectious Disease, Department of Internal Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427, Taiwan.
Department of Internal Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Can J Infect Dis Med Microbiol. 2020 Mar 30;2020:9205197. doi: 10.1155/2020/9205197. eCollection 2020.
is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in . In this study, we aim to determine the occurrence of common virulence genes in using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to bile resistance, chemotaxis, hemolysis, and motility. We detected the existence of , , and III involved in hemolysis. We also found chemotaxis gene cluster operon and gene. The results provide insights into the genetic basis underlying pathogenicity in .
是一种新兴的海洋人畜共患病原体，在免疫功能低下的宿主中导致相当高的死亡率和发病率。然而，关于了解其毒力决定因素的遗传背景的文献很少。在本研究中，我们旨在通过全基因组测序和比较基因组分析来确定中常见毒力基因的存在情况。比较基因组学揭示了与胆汁抗性、趋化性、溶血和运动性相关的假定毒力基因。我们检测到参与溶血的、和III的存在。我们还发现了趋化基因簇操纵子和基因。这些结果为其致病性的遗传基础提供了见解。
