Melley Lauren E, Bress Eli, Polan Erik
Doctor of Osteopathic Medicine Program, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA
Department of Otolaryngology-Head and Neck Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA.
BMJ Case Rep. 2020 May 13;13(5):e236080. doi: 10.1136/bcr-2020-236080.
COVID-19 is the disease caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first arose in Wuhan, China, in December 2019 and has since been declared a pandemic. The clinical sequelae vary from mild, self-limiting upper respiratory infection symptoms to severe respiratory distress, acute cardiopulmonary arrest and death. Otolaryngologists around the globe have reported a significant number of mild or otherwise asymptomatic patients with COVID-19 presenting with olfactory dysfunction. We present a case of COVID-19 resulting in intensive care unit (ICU) admission, presenting with the initial symptom of disrupted taste and flavour perception prior to respiratory involvement. After 4 days in the ICU and 6 days on the general medicine floor, our patient regained a majority of her sense of smell and was discharged with only lingering dysgeusia. In this paper, we review existing literature and the clinical course of SARS-CoV-2 in relation to the reported symptoms of hyposmia, hypogeusia and dysgeusia.
2019冠状病毒病（COVID-19）是由新型冠状病毒，即严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的疾病，该病毒于2019年12月在中国武汉首次出现，随后被宣布为大流行病。其临床后遗症从轻微的、自限性的上呼吸道感染症状到严重的呼吸窘迫、急性心肺骤停和死亡不等。全球的耳鼻喉科医生报告了大量患有2019冠状病毒病的轻症或无症状患者出现嗅觉功能障碍。我们报告一例因2019冠状病毒病入住重症监护病房（ICU）的病例，该患者在出现呼吸道症状之前，最初的症状是味觉和嗅觉感知障碍。在ICU治疗4天和在普通内科病房治疗6天后，我们的患者大部分嗅觉恢复，出院时仅遗留味觉障碍。在本文中，我们回顾了现有文献以及SARS-CoV-2与所报告的嗅觉减退、味觉减退和味觉障碍症状相关的临床病程。
