用光响应二维纳米材料对人干细胞进行光热调节。
Photothermal modulation of human stem cells using light-responsive 2D nanomaterials.
机构信息
Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843.
Department of Biology, Texas A&M University, College Station, TX 77843.
出版信息
Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13329-13338. doi: 10.1073/pnas.1914345117. Epub 2020 May 27.
Two-dimensional (2D) molybdenum disulfide (MoS) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS and NIR stimulation of MoS with human stem cells is investigated using whole-transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence of MoS and NIR stimulation of MoS on integrins, cellular migration, and wound healing. The combination of MoS and NIR light may provide new approaches to regulate and direct these cellular functions for the purposes of regenerative medicine as well as cancer therapy.
二维（2D）二硫化钼（MoS）纳米材料是一类新兴的生物材料，在近红外波长（NIR）下具有光响应性。在这里，我们证明了 2D MoS 通过光热机制调节人类干细胞的细胞功能的能力。使用全转录组测序（RNA-seq）研究了 MoS 与人类干细胞的相互作用以及 MoS 的 NIR 刺激。干细胞的全基因表达谱揭示了 MoS 和 MoS 的 NIR 刺激对整合素、细胞迁移和伤口愈合的显著影响。MoS 和 NIR 光的结合可能为调节和指导这些细胞功能提供新的方法，用于再生医学和癌症治疗。
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