Matharu Rupy Kaur, Ciric Lena, Ren Guogang, Edirisinghe Mohan
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
Department of Civil, Environmental & Geomatic Engineering, University College London, Chadwick Building, Gower Street, London WC1E 6BT, UK.
Nanomaterials (Basel). 2020 May 26;10(6):1017. doi: 10.3390/nano10061017.
A significant proportion of patients acquire hospital associated infections as a result of care within the NHS each year. Numerous antimicrobial strategies, such as antibiotics and surface modifications to medical facilities and instruments, have been devised in an attempt to reduce the incidence of nosocomial infections, but most have been proven unsuccessful and unsustainable due to antibiotic resistance. Therefore, the need to discover novel materials that can combat pathogenic microorganisms is ongoing. Novel technologies, such as the potential use of nanomaterials and nanocomposites, hold promise for reducing these infections in the fight against antimicrobial resistance. In this study, the antimicrobial activity of tungsten, tungsten carbide and tungsten oxide nanoparticles were tested against , and bacteriophage T4 (DNA virus). The most potent nanoparticles, tungsten oxide, were incorporated into polymeric fibres using pressurised gyration and characterised using scanning electron microscopy and energy dispersive X-ray spectroscopy. The antimicrobial activity of tungsten oxide/polymer nanocomposite fibres was also studied. The results suggest the materials in this study promote mediation of the inhibition of microbial growth in suspension.
每年有相当一部分患者在英国国民医疗服务体系（NHS）接受治疗时感染医院相关疾病。为了降低医院感染的发生率，人们设计了许多抗菌策略，如使用抗生素以及对医疗设施和器械进行表面改性，但由于抗生素耐药性，大多数策略已被证明是不成功且不可持续的。因此，持续需要发现能够对抗病原微生物的新型材料。诸如潜在使用纳米材料和纳米复合材料等新技术，有望在抗击抗菌耐药性的斗争中减少这些感染。在本研究中，测试了钨、碳化钨和氧化钨纳米颗粒对 、 和噬菌体T4（DNA病毒）的抗菌活性。最有效的纳米颗粒氧化钨，通过加压旋转法被掺入聚合物纤维中，并使用扫描电子显微镜和能量色散X射线光谱进行表征。还研究了氧化钨/聚合物纳米复合纤维的抗菌活性。结果表明，本研究中的材料促进了悬浮液中微生物生长抑制的介导作用。
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