Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea.
Sci Rep. 2020 Jun 19;10(1):9951. doi: 10.1038/s41598-020-66535-3.
Disrupted reward circuits and diminished behavioural control have been suggested as the pathophysiologies of Internet gaming disorder (IGD). Family functioning is thought to play an important role in reward-related control. We hypothesized that adolescents with IGD show disrupted patterns of family relationships, which are associated with brain activity within the reward circuit. 42 adolescents with IGD without comorbidities and 41 healthy controls were assessed for family function and psychological states using the Korean Wechsler Intelligence Scale for Children (K-WISC), Korean version of DuPaul's attention deficit hyperactivity disorder (ADHD) Rating Scale (K-ARS), Young Internet Addiction Scale (YIAS), Children's Depression Inventory (CDI), Beck Anxiety Inventory (BAI), and the relationship domain of the Family Environmental Scale (FES-R). Brain activity was assessed via resting-state fMRI. Adolescents with IGD showed increased K-ARS, BAI, and YIAS scores, but decreased FES-R and FES-cohesion subscale scores; YIAS scores were negatively correlated with FES-R scores. Brain connectivity from the cingulate to the striatum was decreased, positively correlated with FES-R scores, and negatively correlated with IGD severity. Adolescents with IGD showed disrupted family relationships, which was associated with the severity of the disorder, and dis-connectivity within the reward circuit.
已提出，奖励回路中断和行为控制减弱是网络成瘾障碍（IGD）的病理生理学基础。家庭功能被认为在与奖励相关的控制中起着重要作用。我们假设，有 IGD 的青少年表现出破坏的家庭关系模式，这与奖励回路内的大脑活动有关。 42 名无合并症的 IGD 青少年和 41 名健康对照组使用韩国韦氏儿童智力量表（K-WISC）、韩国版杜保尔注意力缺陷多动障碍（ADHD）评定量表（K-ARS）、青少年网络成瘾量表（YIAS）、儿童抑郁量表（CDI）、贝克焦虑量表（BAI）和家庭环境量表（FES-R）的关系领域评估家庭功能和心理状态。通过静息状态 fMRI 评估大脑活动。IGD 青少年的 K-ARS、BAI 和 YIAS 评分升高，但 FES-R 和 FES-凝聚力子量表评分降低；YIAS 评分与 FES-R 评分呈负相关。从扣带回到纹状体的大脑连接减少，与 FES-R 评分呈正相关，与 IGD 严重程度呈负相关。IGD 青少年表现出破坏的家庭关系，这与疾病的严重程度有关，并且与奖励回路内的失连接有关。
