Institute of Health Services Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Public Health, Graduate School, Yonsei University College of Medicine, Seoul, Republic of Korea.
Sci Rep. 2020 Jun 26;10(1):10467. doi: 10.1038/s41598-020-67524-2.
Few studies have researched the gender-specific effects of electronic nicotine delivery systems on the metabolic syndrome (MetS) and/or its risk factors (central obesity, raised triglycerides, decreased HDL cholesterol, raised blood pressure, raised fasting plasma glucose). Thus, this study investigated the association between smoking behavior (cigarette type, smoking history) and MetS in a nationally representative sample of Korean men and women. Our study employed data for 5,462 cases of MetS and 12,194 controls from the Korea National Health and Nutritional Examination Survey (KNHANES) for the years 2014 to 2017. Logistic regression analysis was employed to determine the association between type of cigarette (non-smoker, ex-smoker, and current smoker-conventional only, current smoker-conventional and electronic) and the prevalence of metabolic syndrome and its risk factors. Smoking history was clinically quantified by pack-year. No association between cigarette type and MetS was found for men. For women, relative to non-smokers, smokers of conventional cigarettes (OR 1.80, 95% CI 1.02-3.18) and both conventional and electronic cigarettes (OR 4.02, 95% CI 1.48-10.93) had increased odds of MetS. While there was no association between smoking history and MetS for women, for men, conventional smoking history was associated with MetS for individuals with a smoking history of > 25 pack-years (> 25 to ≤ 37.5 OR 1.45, 95% CI 1.04-2.02; > 37.5 to ≤ 50 OR 1.53, 95% CI 1.08-2.18; > 50 OR 1.56, 95% CI 1.07-2.27). Sex differences were found in the association between smoking behavior and MetS. Such findings reveal sociodemographic differences that should be considered for interventions regarding conventional and/or e-cigarette users at risk of metabolic complications.
很少有研究探讨电子尼古丁输送系统对代谢综合征（MetS）及其危险因素（中心性肥胖、甘油三酯升高、高密度脂蛋白胆固醇降低、血压升高、空腹血糖升高）的性别特异性影响。因此，本研究调查了吸烟行为（香烟类型、吸烟史）与韩国男女代表性样本中 MetS 之间的关系。我们的研究使用了 2014 年至 2017 年韩国国家健康和营养检查调查（KNHANES）中 5462 例 MetS 病例和 12194 例对照的数据。采用 logistic 回归分析来确定香烟类型（非吸烟者、前吸烟者和当前吸烟者-仅传统香烟、当前吸烟者-传统香烟和电子烟）与代谢综合征及其危险因素的患病率之间的关系。吸烟史通过包年进行临床量化。在男性中，未发现香烟类型与 MetS 之间存在关联。对于女性，与不吸烟者相比，传统香烟吸烟者（OR 1.80，95%CI 1.02-3.18）和同时使用传统香烟和电子烟的吸烟者（OR 4.02，95%CI 1.48-10.93）患 MetS 的几率更高。虽然女性吸烟史与 MetS 之间没有关联，但对于男性来说，吸烟史超过 25 包年（>25 至≤37.5 OR 1.45，95%CI 1.04-2.02；>37.5 至≤50 OR 1.53，95%CI 1.08-2.18；>50 OR 1.56，95%CI 1.07-2.27）与 MetS 相关。在吸烟行为与 MetS 之间的关联中发现了性别差异。这些发现揭示了社会人口统计学差异，在针对有代谢并发症风险的传统和/或电子烟使用者进行干预时应考虑这些差异。
