Scales W E, Vander A J, Brown M B, Kluger M J
Department of Physiology, University of Michigan Medical School, Ann Arbor.
J Appl Physiol (1985). 1988 Oct;65(4):1840-6. doi: 10.1152/jappl.1988.65.4.1840.
The literature supports the concept that circadian changes in body temperature reflect changes in the thermoregulatory set point. We were interested in studying the relationship between the circadian rhythm in body temperature and 24-h variations in plasma concentrations of iron, zinc, circulating leukocyte counts, and plasma interleukin 1 (IL-1) activity. Eight healthy men were studied for two separate 48-h sessions. Rectal temperature, plasma iron and zinc concentrations, plasma IL-1 activity, circulating leukocyte counts, and several other blood variables were monitored. Circadian rhythms in temperature, trace metals, and various leukocyte populations were demonstrated. The 24-h pattern of changes in plasma concentrations of iron and zinc approximate an inverse relationship with rectal temperature. Although we were unable to detect any IL-1 activity in human plasma collected at 4-h intervals, the daily changes in plasma trace metal concentrations and the variations in leukocyte populations may provide indirect evidence for a daily variation in local (e.g., in liver) or central nervous system release of IL-1.
文献支持这样一种观点，即体温的昼夜变化反映了体温调节设定点的变化。我们感兴趣的是研究体温的昼夜节律与血浆中铁、锌浓度、循环白细胞计数以及血浆白细胞介素1（IL-1）活性的24小时变化之间的关系。对8名健康男性进行了两个独立的48小时研究期。监测了直肠温度、血浆铁和锌浓度、血浆IL-1活性、循环白细胞计数以及其他几个血液变量。证明了温度、微量金属和各种白细胞群体的昼夜节律。血浆中铁和锌浓度的24小时变化模式与直肠温度大致呈反比关系。尽管我们无法检测到每隔4小时采集的人体血浆中的任何IL-1活性，但血浆微量金属浓度的每日变化和白细胞群体的变化可能为局部（如肝脏）或中枢神经系统释放IL-1的每日变化提供间接证据。
