AGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom.
PLoS One. 2020 Jul 10;15(7):e0235952. doi: 10.1371/journal.pone.0235952. eCollection 2020.
Dietary protein supplementation combined with resistance exercise (RE) may counteract declines in muscle strength, mass, and function (sarcopenia), but the role of whole foods rich in protein, such as milk, is less well understood. In the MIlkMAN study, we aimed to examine the feasibility and acceptability of milk+RE as an intervention for muscle function in community-dwelling older adults, and provide exploratory pilot data for future substantive research in population at risk of sarcopenia.
In a parallel groups design, 30 older adults (71.7±3.6 years; 12 women) were randomised into three groups: WM (whole milk 3.6% fat)+RE, SM (skimmed milk 0.3% fat)+RE, and C (isocaloric carbohydrate drink)+RE. RE was performed twice-weekly over 6 weeks in a community gym, followed by the consumption of 500 ml of milk (~20 g protein) or carbohydrate drink immediately after exercise and a further 500 ml at home within the following 4-5 hours. The feasibility and acceptability of the study was determined by calculating recruitment and attendance rates, compliance with the intervention, rating participants' experiences, and recording adverse health events.
The response rate was 49% (out of 400 invitations sent), and the recruitment rate was 73.2% (30 participants recruited out of 41 screened for eligibility). Twenty-nine participants completed the intervention-an attendance rate of 97.1%; 89.7% rated their experience as 'excellent'/very good'. Compliance with taking the drinks was 97.1% (WM), 98.3% (SM), and 95.0% (C); 93.1% rated their drink intake as 'easy'/'very easy' with no adverse effects. Collection of exploratory pilot data to inform future trials was successful. Mean change in grip strength, 5-chair rises, and gait speed were 0.9±3.4 kg, 1.8±2.2 s, 0.1±0.1 m/s, respectively with no differences between the groups.
This community-based milk+RE intervention was feasible and acceptable to older adults. The study successfully collected pilot data for future substantive research.
膳食蛋白质补充剂与抗阻运动（RE）相结合可能会阻止肌肉力量、质量和功能（肌少症）的下降，但富含蛋白质的全食物（如牛奶）的作用还不太清楚。在 MilkMAN 研究中，我们旨在研究牛奶+RE 作为社区居住的老年人肌肉功能干预措施的可行性和可接受性，并为肌肉减少症风险人群的未来实质性研究提供探索性试点数据。
采用平行分组设计，将 30 名老年人（71.7±3.6 岁；12 名女性）随机分为三组：WM（全脂牛奶 3.6%脂肪）+RE、SM（脱脂牛奶 0.3%脂肪）+RE 和 C（等热量碳水化合物饮料）+RE。RE 在社区健身房每周进行两次，共 6 周，之后在运动后立即饮用 500 毫升牛奶（约 20 克蛋白质）或碳水化合物饮料，并在接下来的 4-5 小时内在家中再饮用 500 毫升。通过计算招募和出席率、干预措施的依从性、评估参与者的体验以及记录不良健康事件来确定研究的可行性和可接受性。
应答率为 49%（400 份邀请中的 49 份），招募率为 73.2%（30 名参与者从 41 名符合条件的参与者中筛选出来）。29 名参与者完成了干预措施——出席率为 97.1%；89.7%的人对他们的体验评价为“优秀”/非常好。服用饮料的依从性分别为 97.1%（WM）、98.3%（SM）和 95.0%（C）；93.1%的人认为他们的饮料摄入量“容易”/非常容易，没有不良反应。成功收集了未来试验的探索性试点数据。握力、5 椅站立和步速的平均变化分别为 0.9±3.4 千克、1.8±2.2 秒和 0.1±0.1 米/秒，组间无差异。
这项基于社区的牛奶+RE 干预措施对老年人来说是可行和可接受的。该研究成功地为未来的实质性研究收集了试点数据。
