Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34113, Korea.
Cells. 2020 Jul 14;9(7):1692. doi: 10.3390/cells9071692.
Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redoxbalance. Peroxisomal function is central to fatty acid oxidation, ether phospholipid synthesis, bile acidsynthesis, and reactive oxygen species homeostasis. Human disorders caused by genetic mutations inperoxisome genes have led to extensive studies on peroxisome biology. Peroxisomal defects are linkedto metabolic dysregulation in diverse human diseases, such as neurodegeneration and age-relateddisorders, revealing the significance of peroxisome metabolism in human health. Cancer is a diseasewith metabolic aberrations. Despite the critical role of peroxisomes in cell metabolism, the functionaleects of peroxisomes in cancer are not as well recognized as those of other metabolic organelles,such as mitochondria. In addition, the significance of peroxisomes in cancer is less appreciated thanit is in degenerative diseases. In this review, I summarize the metabolic pathways in peroxisomesand the dysregulation of peroxisome metabolism in cancer. In addition, I discuss the potential ofinactivating peroxisomes to target cancer metabolism, which may pave the way for more eectivecancer treatment.
过氧化物酶体是参与脂质代谢和细胞氧化还原平衡的代谢细胞器。过氧化物酶体的功能对于脂肪酸氧化、醚磷脂合成、胆汁酸合成和活性氧物种平衡至关重要。由于过氧化物酶体基因的基因突变导致的人类疾病，促使人们对过氧化物酶体生物学进行了广泛的研究。过氧化物酶体缺陷与多种人类疾病中的代谢失调有关，如神经退行性疾病和与年龄相关的疾病，这揭示了过氧化物体代谢在人类健康中的重要性。癌症是一种代谢异常的疾病。尽管过氧化物体在细胞代谢中起着关键作用，但过氧化物体在癌症中的功能作用尚未得到像线粒体等其他代谢细胞器那样的充分认识。此外，过氧化物体在癌症中的重要性不如在退行性疾病中那么受到重视。在这篇综述中，我总结了过氧化物体中的代谢途径以及过氧化物体代谢在癌症中的失调。此外，我还讨论了使过氧化物体失活以靶向癌症代谢的潜力，这可能为更有效的癌症治疗铺平道路。
