提高体外生物打印容积肿瘤微环境。
Improving Bioprinted Volumetric Tumor Microenvironments In Vitro.
机构信息
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
出版信息
Trends Cancer. 2020 Sep;6(9):745-756. doi: 10.1016/j.trecan.2020.06.002. Epub 2020 Jul 14.
Abstract
Despite the great breakthroughs in the past few decades in illuminating the pathological mechanisms of cancer and in developing new anticancer drugs, it remains extremely challenging to cure most cancers. Therefore, it is imperative to develop more sophisticated and more biomimetic preclinical cancer models. 3D models combined with dynamic culture techniques show great potential to accurately emulate the volumetric tumor microenvironment (TME). Here we introduce advances in bioprinting technologies for in vitro cancer modeling and their applications. Finally, we look ahead to the remaining challenges associated with current bioprinting strategies for achieving faithful cancer modeling.
摘要
尽管在过去几十年中，癌症的病理机制阐明和新型抗癌药物的开发方面取得了重大突破，但要治愈大多数癌症仍然极具挑战性。因此，开发更复杂、更仿生的临床前癌症模型势在必行。结合动态培养技术的 3D 模型具有准确模拟肿瘤微环境（TME）的巨大潜力。本文介绍了用于体外癌症建模的生物打印技术的进展及其应用。最后，我们展望了当前生物打印策略在实现真实癌症建模方面面临的挑战。
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