Optical Sciences Centre, School of Science, Swinburne University of Technology, Hawthorn, VIC, Australia.
ARC Industrial Transformation Training Centre in Surface Engineering for Advanced Materials, School of Science, Swinburne University of Technology, Hawthorn, VIC, Australia.
Nat Rev Microbiol. 2021 Jan;19(1):8-22. doi: 10.1038/s41579-020-0414-z. Epub 2020 Aug 17.
Antibiotic resistance is a global human health threat, causing routine treatments of bacterial infections to become increasingly difficult. The problem is exacerbated by biofilm formation by bacterial pathogens on the surfaces of indwelling medical and dental devices that facilitate high levels of tolerance to antibiotics. The development of new antibacterial nanostructured surfaces shows excellent prospects for application in medicine as next-generation biomaterials. The physico-mechanical interactions between these nanostructured surfaces and bacteria lead to bacterial killing or prevention of bacterial attachment and subsequent biofilm formation, and thus are promising in circumventing bacterial infections. This Review explores the impact of surface roughness on the nanoscale in preventing bacterial colonization of synthetic materials and categorizes the different mechanisms by which various surface nanopatterns exert the necessary physico-mechanical forces on the bacterial cell membrane that will ultimately result in cell death.
抗生素耐药性是一个全球性的人类健康威胁，导致细菌感染的常规治疗变得越来越困难。细菌病原体在留置的医疗和牙科设备表面形成生物膜，使细菌对抗生素的耐受性提高，从而使问题更加严重。具有抗菌性能的纳米结构化表面的开发为作为下一代生物材料的应用展示了广阔的前景。这些纳米结构化表面与细菌之间的物理-机械相互作用导致细菌杀伤或防止细菌附着和随后的生物膜形成，因此在规避细菌感染方面很有前景。本综述探讨了表面粗糙度在纳米尺度上对防止合成材料中细菌定植的影响，并对各种表面纳米图案通过何种不同机制对细菌细胞膜施加必要的物理-机械力进行了分类，最终导致细胞死亡。
