检测老年人中免疫球蛋白M反应以早期诊断呼吸道合胞病毒感染。
Detection of an immunoglobulin M response in the elderly for early diagnosis of respiratory syncytial virus infection.
作者信息
Vikerfors T, Grandien M, Johansson M, Pettersson C A
机构信息
Department of Infectious Diseases, Orebro Medical Center Hospital, Sweden.
出版信息
J Clin Microbiol. 1988 May;26(5):808-11. doi: 10.1128/jcm.26.5.808-811.1988.
Abstract
The indirect fluorescent-antibody technique was compared with indirect and mu-capture enzyme-linked immunosorbent assays for the detection of respiratory syncytial virus (RSV) immunoglobulin M (IgM) in the elderly. Sera from 47 patients (mean age, 70 years) with acute lower respiratory tract infections caused by RSV were investigated. Specific IgM was detected in 81% (38 of 47) of the patients. The fluorescent-antibody technique, which gave 70% positive results, proved to be the most sensitive of the three methods. An IgM response was seldom seen in sera from the elderly within the first week of disease, but was present in 85% of sera (33 of 39) collected between days 11 and 30 of disease. In some patients it persisted for more than 6 weeks. Detection of IgM was found to be a useful tool for the diagnosis of RSV infections in elderly patients.
摘要
为检测老年人呼吸道合胞病毒（RSV）免疫球蛋白M（IgM），对间接荧光抗体技术与间接和μ捕获酶联免疫吸附试验进行了比较。研究了47例（平均年龄70岁）由RSV引起的急性下呼吸道感染患者的血清。在81%（47例中的38例）的患者中检测到特异性IgM。荧光抗体技术的阳性结果为70%，被证明是三种方法中最敏感的。在疾病的第一周内，老年人血清中很少出现IgM反应，但在疾病第11天至30天之间采集的血清中，85%（39例中的33例）出现了IgM反应。在一些患者中，IgM反应持续超过6周。发现检测IgM是诊断老年患者RSV感染的有用工具。
相似文献
1
Detection of an immunoglobulin M response in the elderly for early diagnosis of respiratory syncytial virus infection.检测老年人中免疫球蛋白M反应以早期诊断呼吸道合胞病毒感染。
J Clin Microbiol. 1988 May;26(5):808-11. doi: 10.1128/jcm.26.5.808-811.1988.
2
Immunoglobulin class-specific antibody response in respiratory syncytial virus infection measured by enzyme immunoassay.通过酶免疫测定法检测呼吸道合胞病毒感染中免疫球蛋白类别特异性抗体反应。
J Med Virol. 1984;14(1):67-72. doi: 10.1002/jmv.1890140110.
3
Capture-ELISA for serum IgM antibody to respiratory syncytial virus.呼吸道合胞病毒血清IgM抗体捕获酶联免疫吸附测定
J Hyg (Lond). 1986 Dec;97(3):511-7. doi: 10.1017/s0022172400063713.
4
Serodiagnosis of respiratory syncytial virus (RSV) infection in children as measured by detection of RSV-specific immunoglobulins G, M, and A with enzyme-linked immunosorbent assay.通过酶联免疫吸附测定法检测呼吸道合胞病毒（RSV）特异性免疫球蛋白G、M和A来对儿童呼吸道合胞病毒（RSV）感染进行血清学诊断。
J Clin Microbiol. 1990 Jan;28(1):152-5. doi: 10.1128/jcm.28.1.152-155.1990.
5
6
Class-specific antibodies to bovine respiratory syncytial virus in experimentally infected lambs.实验感染羔羊体内针对牛呼吸道合胞体病毒的类特异性抗体。
Epidemiol Infect. 1992 Feb;108(1):135-45. doi: 10.1017/s095026880004958x.
7
Comparison of fluorescent-antibody, neutralizing-antibody, and complement-enhanced neutralizing-antibody assays for detection of serum antibody to respiratory syncytial virus.荧光抗体、中和抗体及补体增强中和抗体检测法用于检测呼吸道合胞病毒血清抗体的比较
J Clin Microbiol. 1981 May;13(5):957-62. doi: 10.1128/jcm.13.5.957-962.1981.
8
Local and systemic antibody response to bovine respiratory syncytial virus infection and reinfection in calves with and without maternal antibodies.有或无母源抗体的犊牛对牛呼吸道合胞体病毒感染和再感染的局部和全身抗体反应。
J Clin Microbiol. 1987 Jun;25(6):1097-106. doi: 10.1128/jcm.25.6.1097-1106.1987.
9
Rapid diagnosis of respiratory syncytial virus infection by antigen immunofluorescence detection with monoclonal antibodies and immunoglobulin M immunofluorescence test.采用单克隆抗体抗原免疫荧光检测和免疫球蛋白M免疫荧光试验对呼吸道合胞病毒感染进行快速诊断。
J Clin Microbiol. 1986 Dec;24(6):1038-40. doi: 10.1128/jcm.24.6.1038-1040.1986.
10
Detection of antibody to respiratory syncytial virus by membrane fluorescence.通过膜荧光检测呼吸道合胞病毒抗体
Clin Exp Immunol. 1976 Oct;26(1):78-85.
引用本文的文献
1
A duplex recombinant viral nucleoprotein microbead immunoassay for simultaneous detection of seroresponses to human respiratory syncytial virus and metapneumovirus infections.一种用于同时检测针对人呼吸道合胞病毒和偏肺病毒感染的血清反应的双链重组病毒核蛋白微珠免疫测定法。
J Virol Methods. 2014 Sep;206:55-62. doi: 10.1016/j.jviromet.2014.05.008. Epub 2014 May 23.
2
The diagnosis of viral respiratory disease in older adults.老年人病毒性呼吸道疾病的诊断。
Clin Infect Dis. 2010 Mar 1;50(5):747-51. doi: 10.1086/650486.
3
Community-acquired viral pneumonia.社区获得性病毒性肺炎
Clin Geriatr Med. 2007 Aug;23(3):535-52, vi. doi: 10.1016/j.cger.2007.02.002.
4
Respiratory syncytial virus infection in elderly adults.老年人呼吸道合胞病毒感染
Drugs Aging. 2005;22(7):577-87. doi: 10.2165/00002512-200522070-00004.
5
A critical role for induced IgM in the protection against West Nile virus infection.诱导性IgM在抵御西尼罗河病毒感染中起关键作用。
J Exp Med. 2003 Dec 15;198(12):1853-62. doi: 10.1084/jem.20031223. Epub 2003 Dec 8.
6
Respiratory syncytial virus infection in adults.成人呼吸道合胞病毒感染
Clin Microbiol Rev. 2000 Jul;13(3):371-84. doi: 10.1128/CMR.13.3.371.
7
Respiratory viral infections in the elderly.老年人的呼吸道病毒感染
Antiviral Res. 1999 Dec 15;44(2):79-102. doi: 10.1016/s0166-3542(99)00062-5.
8
Respiratory syncytial virus infection in the elderly.老年人呼吸道合胞病毒感染
Eur J Clin Microbiol Infect Dis. 1996 Oct;15(10):777-81. doi: 10.1007/BF01701518.
9
Outbreak of vertigo in Wyoming: possible role of an enterovirus infection.怀俄明州眩晕症爆发：肠道病毒感染的可能作用。
Epidemiol Infect. 1996 Aug;117(1):149-57. doi: 10.1017/s0950268800001254.
10
Diagnosis of influenza A virus infections by detection of specific immunoglobulins M, A, and G in serum.通过检测血清中特异性免疫球蛋白M、A和G来诊断甲型流感病毒感染。
J Clin Microbiol. 1989 Mar;27(3):453-8. doi: 10.1128/jcm.27.3.453-458.1989.
本文引用的文献
1
Systemic cell-mediated and antibody responses in infants with respiratory syncytial virus infections.
J Med Virol. 1980;5(2):161-70. doi: 10.1002/jmv.1890050210.
2
The antibody response to primary and secondary infection with respiratory syncytial virus: kinetics of class-specific responses.针对呼吸道合胞病毒初次感染和二次感染的抗体反应：类特异性反应的动力学
J Pediatr. 1980 May;96(5):808-13. doi: 10.1016/s0022-3476(80)80547-6.
3
Use of a simple, new test for virus-specific IgM to investigate an outbreak of influenza B in a hospitalised aged community.
J Virol Methods. 1982 Feb;4(1):9-18. doi: 10.1016/0166-0934(82)90049-0.
4
Respiratory syncytial virus pneumonitis in adults.
Med J Aust. 1983 Apr 30;1(9):430-1. doi: 10.5694/j.1326-5377.1983.tb136145.x.
5
Immunoglobulin class-specific antibody response in respiratory syncytial virus infection measured by enzyme immunoassay.通过酶免疫测定法检测呼吸道合胞病毒感染中免疫球蛋白类别特异性抗体反应。
J Med Virol. 1984;14(1):67-72. doi: 10.1002/jmv.1890140110.
6
Diagnosis of respiratory syncytial virus infection in children: comparison of viral antigen detection and serology.儿童呼吸道合胞病毒感染的诊断：病毒抗原检测与血清学检测的比较
J Med Virol. 1984;14(1):61-5. doi: 10.1002/jmv.1890140109.
7
Detection by ELISA of IgA and IgM antibodies in secretion and IgM antibodies in serum in primary lower respiratory syncytial virus infection.
J Med Virol. 1984;13(2):149-61. doi: 10.1002/jmv.1890130205.
8
Acute lower respiratory illness in elderly patients with respiratory syncytial virus infection.
Acta Med Scand. 1967 Sep;182(3):323-30. doi: 10.1111/j.0954-6820.1967.tb11530.x.
9
Rapid diagnosis of respiratory syncytial virus infection by immunofluorescent antibody techniques.通过免疫荧光抗体技术对呼吸道合胞病毒感染进行快速诊断。
Br Med J. 1968 Mar 9;1(5592):602-5. doi: 10.1136/bmj.1.5592.602.
10
Respiratory syncytial virus infections in adults.成人呼吸道合胞病毒感染
Am Rev Respir Dis. 1987 Sep;136(3):561-4. doi: 10.1164/ajrccm/136.3.561.
Zotero 插件