Postgraduate Program in Environment, São Luís, Maranhão, Brazil.
Postgraduate Program in Microbial Biology, CEUMA University, São Luís, Maranhão, Brazil.
Biosci Rep. 2020 Sep 30;40(9). doi: 10.1042/BSR20200634.
Asthma is a disease that has been associated with the presence of different genetic and socio-environmental factors.
To identify and evaluate the seasonality of respiratory syncytial virus (RSV) and human rhinovirus (RV) in asthmatic children and adolescents in tropical climate, as well as to assess the socioeconomic and environmental factors involved.
The study was conducted in a referral hospital, where a total of 151 children were recruited with a respiratory infection. The International Study of Asthma and Allergies in Childhood (ISAAC) protocol and a questionnaire were applied, and a skin prick test was performed. The nasal swab was collected to detect RV and RSV through molecular assay. National Meteorological Institute (INMET) database was the source of climatic information.
The socio-environmental characterization of asthmatic children showed the family history of allergy, disturbed sleep at night, dry cough, allergic rhinitis, individuals sensitized to at least one mite. We identified RV in 75% of children with asthma and 66.7% of RSV in children with asthma. There was an association between the presence of RV and the dry season whereas the presence of the RSV was associated with the rainy season. Contributing to these results, a negative correlation was observed between the RSV and the wind speed and the maximum temperature (T. Max) and a positive correlation with precipitation.
The results suggest a high prevalence of RV and RSV in asthmatic children and the seasonality of these viruses were present in different climatic periods. This has significant implications for understanding short- and long-term clinical complications in asthmatic patients.
哮喘是一种与多种遗传和社会环境因素有关的疾病。
在热带气候条件下，确定并评估呼吸道合胞病毒（RSV）和人类鼻病毒（RV）在哮喘儿童和青少年中的季节性，同时评估相关的社会经济和环境因素。
本研究在一家转诊医院进行，共招募了 151 名患有呼吸道感染的儿童。采用国际儿童哮喘和过敏研究（ISAAC）方案和问卷进行调查，并进行皮肤点刺试验。采集鼻拭子，通过分子检测法检测 RV 和 RSV。国家气象研究所（INMET）数据库是气候信息的来源。
哮喘儿童的社会环境特征显示，有过敏家族史、夜间睡眠不安、干咳、过敏性鼻炎、对至少一种螨虫过敏的个体。我们发现，哮喘儿童中 RV 的检出率为 75%，而 RSV 的检出率为 66.7%。RV 的存在与旱季有关，而 RSV 的存在与雨季有关。这些结果表明，RSV 与风速和最高温度（T. Max）呈负相关，与降水呈正相关。
研究结果表明，RV 和 RSV 在哮喘儿童中普遍存在，这些病毒的季节性存在于不同的气候期。这对理解哮喘患者的短期和长期临床并发症具有重要意义。
