Martinez-Enriquez Eduardo, de Castro Alberto, Marcos Susana
Consejo Superior de Investigaciones Científicas (CSIC), Calle Serrano 121, Madrid, 28006, Spain.
Biomed Opt Express. 2020 Sep 16;11(10):5633-5649. doi: 10.1364/BOE.397695. eCollection 2020 Oct 1.
The crystalline lens is an important optical element in the eye, responsible for focusing, and which experiences significant changes throughout life. The shape of the lens is usually studied only in the optical area (central 4 to 6 mm). However, for a great number of applications, a description of the full shape of the crystalline lens is required. We propose a new method for the representation of the full shape of the crystalline lens, constructed from 3-dimensional optical coherence tomography images of 133 isolated crystalline lenses (0-71 y/o), which we have called . The method is shown to be compact and accurate to describe not only the full shape of the crystalline lens, but also the optical zone in comparison with other methods. We also demonstrate its application to the extrapolation of the full shape of the crystalline lens from optical images of the anterior segment of the eye, where only the central part of the lens visible through the pupil is available, and in the generation (synthesis) of realistic full lenses of a given age. The method has critical applications, among others, in improving and evaluating myopia and presbyopia treatments.
晶状体是眼睛中的一个重要光学元件，负责聚焦，并且在整个生命过程中会经历显著变化。晶状体的形状通常仅在光学区域（中心4至6毫米）进行研究。然而，对于大量应用而言，需要对晶状体的完整形状进行描述。我们提出了一种表示晶状体完整形状的新方法，该方法由133个分离的晶状体（0至71岁）的三维光学相干断层扫描图像构建而成，我们将其称为 。与其他方法相比，该方法不仅能够紧凑且准确地描述晶状体的完整形状，还能描述光学区域。我们还展示了其在前节眼光学图像中推断晶状体完整形状的应用，在前节眼光学图像中，只能通过瞳孔看到晶状体的中央部分，以及在生成（合成）给定年龄的逼真完整晶状体方面的应用。该方法在改善和评估近视及老花眼治疗等方面具有关键应用。
