School of Integrated Technology, Yonsei University, Incheon, 21983, Republic of Korea.
Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Nat Commun. 2020 Nov 19;11(1):5896. doi: 10.1038/s41467-020-19750-5.
The process of memory and learning in biological systems is multimodal, as several kinds of input signals cooperatively determine the weight of information transfer and storage. This study describes a peptide-based platform of materials and devices that can control the coupled conduction of protons and electrons and thus create distinct regions of synapse-like performance depending on the proton activity. We utilized tyrosine-rich peptide-based films and generalized our principles by demonstrating both memristor and synaptic devices. Interestingly, even memristive behavior can be controlled by both voltage and humidity inputs, learning and forgetting process in the device can be initiated and terminated by protons alone in peptide films. We believe that this work can help to understand the mechanism of biological memory and lay a foundation to realize a brain-like device based on ions and electrons.
生物系统中的记忆和学习过程是多模态的，因为几种输入信号协同决定了信息传递和存储的权重。本研究描述了一种基于肽的材料和器件平台，它可以控制质子和电子的耦合传导，从而根据质子活性创造出类似突触的性能的不同区域。我们利用富含酪氨酸的肽基薄膜，并通过演示忆阻器和突触器件来推广我们的原理。有趣的是，即使是忆阻行为也可以同时通过电压和湿度输入来控制，在肽膜中，质子可以单独启动和终止器件中的学习和遗忘过程。我们相信这项工作有助于理解生物记忆的机制，并为实现基于离子和电子的类脑设备奠定基础。
