Watts F Z, Shiels G, Orr E
Department of Genetics, University of Leicester, UK.
EMBO J. 1987 Nov;6(11):3499-505. doi: 10.1002/j.1460-2075.1987.tb02675.x.
A yeast gene MYO1 that contains regions of substantial sequence homology with the nematode muscle myosin gene (unc54) has been isolated and sequenced. Although the disruption of MYO1 is not lethal, it leads to aberrant nuclear migration and cytokinesis. The 200-kd myosin heavy chain-like protein, the product of MYO1, cross-reacts with anti-nematode myosin heavy chain IgG and is present in wild-type strains but not in strains carrying the disrupted gene. Instead, a truncated polypeptide with a molecular mass of 120 kd can be detected in some myo1 mutants.
一个与线虫肌肉肌球蛋白基因（unc54）具有大量序列同源区域的酵母基因MYO1已被分离和测序。虽然MYO1的破坏并非致命，但它会导致异常的核迁移和胞质分裂。MYO1的产物、一种200kd的肌球蛋白重链样蛋白，可与抗线虫肌球蛋白重链IgG发生交叉反应，存在于野生型菌株中，但不存在于携带被破坏基因的菌株中。相反，在一些myo1突变体中可检测到一种分子量为120kd的截短多肽。
