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心室组织工程的当前技术水平

Current State of the Art in Ventricle Tissue Engineering.

作者信息

Birla Ravi K

机构信息

BIOLIFE4D, Houston, TX, United States.

出版信息

Front Cardiovasc Med. 2020 Nov 3;7:591581. doi: 10.3389/fcvm.2020.591581. eCollection 2020.

DOI:10.3389/fcvm.2020.591581
PMID:33240941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7669614/
Abstract

The field of ventricle tissue engineering is focused on bioengineering highly functioning left ventricles that can be used as model systems for basic cardiology research and for cardiotoxicity testing. In this article, we review the current state of the art in the field of ventricle tissue engineering and discuss different strategies that have been used to bioengineer ventricles. Based on this body of literature, there are now common themes in the field that provide guidance for future directives, also presented in this article.

摘要

心室组织工程领域专注于生物工程构建高功能的左心室，这些左心室可作为基础心脏病学研究和心脏毒性测试的模型系统。在本文中，我们综述了心室组织工程领域的当前技术水平，并讨论了用于生物工程构建心室的不同策略。基于这一文献体系，该领域目前存在一些共同主题，可为未来的研究方向提供指导，本文也将予以介绍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48da/7669614/52b632781c9d/fcvm-07-591581-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48da/7669614/88548e176dd5/fcvm-07-591581-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48da/7669614/8aadb2e745e7/fcvm-07-591581-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48da/7669614/52b632781c9d/fcvm-07-591581-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48da/7669614/88548e176dd5/fcvm-07-591581-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48da/7669614/8aadb2e745e7/fcvm-07-591581-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48da/7669614/52b632781c9d/fcvm-07-591581-g0003.jpg

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2
Bioengineering Vascular Networks to Study Angiogenesis and Vascularization of Physiologically Relevant Tissue Models .生物工程血管网络以研究生理相关组织模型中的血管生成和血管化。
ACS Biomater Sci Eng. 2020 Jun 8;6(6):3513-3528. doi: 10.1021/acsbiomaterials.0c00191. Epub 2020 Apr 29.
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Vascular Tissue Engineering: Advanced Techniques and Gene Editing in Stem Cells for Graft Generation.
血管组织工程：用于移植物生成的干细胞先进技术与基因编辑
Tissue Eng Part B Rev. 2021 Feb;27(1):14-28. doi: 10.1089/ten.TEB.2019.0264. Epub 2020 Jul 27.
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Current challenges in three-dimensional bioprinting heart tissues for cardiac surgery.三维生物打印心脏组织用于心脏手术的当前挑战。
Eur J Cardiothorac Surg. 2020 Sep 1;58(3):500-510. doi: 10.1093/ejcts/ezaa093.
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Nanomaterials (Basel). 2020 May 5;10(5):887. doi: 10.3390/nano10050887.
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