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富含血小板血浆与基质血管成分联合应用对大鼠深度真皮烧伤创面转化生长因子-β水平的影响

Combination of platelet-rich plasma and stromal vascular fraction on the level of transforming growth factor-β in rat subjects experiencing deep dermal burn injury.

作者信息

Laidding Sachraswaty Rachman, Josh Fonny, Faruk Muhammad, Palissei Andi Sinapati, Satria Bayu, Bukhari Agussalim, Massi Muh Nassrum, Islam Andi Asadul

机构信息

Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

出版信息

Ann Med Surg (Lond). 2020 Dec 8;60:737-742. doi: 10.1016/j.amsu.2020.11.088. eCollection 2020 Dec.

DOI:10.1016/j.amsu.2020.11.088
PMID:33425344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7779951/
Abstract

INTRODUCTION: The combination of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) is effective at increasing the concentration of growth factors including transforming growth factor-β (TGF-β). The increase in this growth factor is expected to accelerate the healing of burns. This study aims to determine the effect of giving a combination of SVFs and PRP on TGF-β levels in the healing process of deep dermal burns. METHODS: This was an experimental study in 64 rats using a post-test control group design consisting of 1 group of SVFs and PRP combination injection treatment group, 1 group given a topical combination of SVFs and PRP, 1 group given Vaseline, and 1 control group. RESULTS: There was a significant difference in TGF-β levels between the deep dermal burns group that was given a combination of SVFs and PRP injection and topical, the Vaseline group, and the control group with p-value <0.05. CONCLUSION: The combination of SVFs and PRP increases the level of TGF-β in the healing process of deep dermal burns.

摘要

引言：基质血管成分（SVF）和富血小板血浆（PRP）的组合在提高包括转化生长因子-β（TGF-β）在内的生长因子浓度方面是有效的。这种生长因子的增加有望加速烧伤的愈合。本研究旨在确定给予SVF和PRP组合对深二度烧伤愈合过程中TGF-β水平的影响。 方法：这是一项对64只大鼠进行的实验研究，采用测试后对照组设计，包括1组SVF和PRP联合注射治疗组、1组给予SVF和PRP局部联合用药组、1组给予凡士林组和1个对照组。 结果：给予SVF和PRP联合注射及局部用药的深二度烧伤组、凡士林组和对照组之间的TGF-β水平存在显著差异，p值<0.05。 结论：SVF和PRP的组合可提高深二度烧伤愈合过程中TGF-β的水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/7779951/e7d530cf2d19/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/7779951/ae72711da64e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/7779951/c6e815800c3b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/7779951/e7d530cf2d19/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/7779951/ae72711da64e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/7779951/c6e815800c3b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/7779951/e7d530cf2d19/gr3.jpg

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Ann Burns Fire Disasters. 2023-6-30

[2]
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Ann Burns Fire Disasters. 2024-3-31

[3]
The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Increases Fibroblast Growth Factor 7 and Promotes Angiogenesis in Full Thickness Burn Injury: Rat Experimental Study.

Ann Burns Fire Disasters. 2023-9-30

[4]
The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Mediates the Inflammatory Process in Deep Dermal Burn Injury.

Ann Burns Fire Disasters. 2023-12-31

[5]
The Effects of High Fat Diet on the Incidence of Obesity and Monocyte Chemoattractant Protein-1 Levels on Histological Changes in Prostate Wistar Rats.

Res Rep Urol. 2024-3-5

[6]
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[7]
Advances and prospects of platelet-rich plasma therapy in veterinary ophthalmology.

Vet Res Commun. 2023-9

[8]
The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Reduces Malondialdehyde and Nitric Oxide Levels in Deep Dermal Burn Injury.

J Inflamm Res. 2021-7-8

[9]
Combination of platelet rich plasma and stromal vascular fraction on the level of vascular endothelial growth factor in rat subjects experiencing deep dermal burn injury.

Ann Med Surg (Lond). 2021-3-26

[10]
High-fat diet increases the level of circulating Monocyte Chemoattractant Protein-1 in Wistar rats, independent of obesity.

Ann Med Surg (Lond). 2021-4-1

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[1]
Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study.

Ann Med Surg (Lond). 2020-9-2

[2]
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Ann Med Surg (Lond). 2020-7-22

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