Saltzberg D M, Levine G M, Lubar C
Division of Gastroenterology and Nutrition, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
Dig Dis Sci. 1988 Mar;33(3):308-13. doi: 10.1007/BF01535755.
In order to evaluate factors that may influence H2 generation, the effects of age, sex, race, and functional complaints on breath H2 were studied in 62 subjects. These included 34 young hospital employees, 17 healthy ambulatory elderly subjects, and 11 patients with functional bowel disease. The ability to produce H2 was defined by an increase in breath H2 to greater than 20 parts per million within 4 hr of ingesting 10 g of the nonabsorbable sugar lactulose. Overall, 21% of subjects were nonproducers, and the incidence of nonproduction did not vary among the groups. The elderly subjects had significantly greater breath H2 concentrations than the younger subjects at 150 minutes (P less than 0.05). Sex, race, and functional complaints did not influence H2 production. These findings indicate that patient's age and potential inability to make H2 need to be considered in the routine interpretation of H2 breath tests.
为了评估可能影响氢气生成的因素，我们对62名受试者的年龄、性别、种族和功能性主诉对呼出氢气的影响进行了研究。这些受试者包括34名年轻的医院工作人员、17名健康的非卧床老年人和11名功能性肠病患者。产生氢气的能力通过摄入10克不可吸收的糖乳果糖后4小时内呼出氢气增加至大于百万分之20来定义。总体而言，21%的受试者不产生氢气，且不产生氢气的发生率在各组之间没有差异。在150分钟时，老年受试者呼出氢气的浓度明显高于年轻受试者（P小于0.05）。性别、种族和功能性主诉不影响氢气生成。这些发现表明，在对氢气呼气试验进行常规解读时，需要考虑患者的年龄以及产生氢气的潜在能力。
