Forbes Scott C, Candow Darren G, Ferreira Luis H B, Souza-Junior Tacito P
Department of Physical Education, Faculty of Education, Brandon University, Brandon, MB, Canada.
Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, Canada.
J Diet Suppl. 2022;19(3):318-335. doi: 10.1080/19390211.2021.1877232. Epub 2021 Jan 27.
Aging is associated with reductions in muscle and bone mass and brain function, which may be counteracted by several lifestyle factors, of which exercise appears to be most beneficial. However, less than 20% of older adults (> 55 years of age) adhere to performing the recommended amount of resistance training (≥ 2 days/week) and less than 12% regularly meet the aerobic exercise guidelines (≥ 150 min/week of moderate to vigorous intensity aerobic exercise) required to achieve significant health benefits. Therefore, from a healthy aging and clinical perspective, it is important to determine whether other lifestyle interventions (independent of exercise) can have beneficial effects on aging muscle quality and quantity, bone strength, and brain function. Creatine, a nitrogen containing organic compound found in all cells of the body, has the potential to have favorable effects on muscle, bone, and brain health (independent of exercise) in older adults. The purpose of this narrative review is to examine and summarize the small body of research investigating the effects of creatine supplementation alone on measures of muscle mass and performance, bone mineral and strength, and indices of brain health in older adults.
衰老与肌肉量、骨量及脑功能的下降有关，而多种生活方式因素可能会抵消这些影响，其中运动似乎最为有益。然而，年龄超过55岁的老年人中，坚持进行推荐量抗阻训练（每周≥2天）的不足20%，定期达到有氧运动指南（每周≥150分钟中等至剧烈强度有氧运动）要求以获得显著健康益处的不足12%。因此，从健康老龄化和临床角度来看，确定其他生活方式干预措施（与运动无关）是否能对衰老肌肉的质量和数量、骨强度及脑功能产生有益影响很重要。肌酸是一种存在于人体所有细胞中的含氮有机化合物，有可能对老年人的肌肉、骨骼和脑健康（与运动无关）产生有利影响。本叙述性综述的目的是审视并总结少量关于单独补充肌酸对老年人肌肉量和性能指标、骨矿物质和强度以及脑健康指标影响的研究。
