Sheikh Khalifa International University Hospital, Faculty of Medicine, Mohammed VI University of Health Sciences, Casablanca, Morocco.
International School of Public Health, Mohammed VI University of Health Sciences, Casablanca, Morocco.
PLoS One. 2021 Feb 4;16(2):e0246295. doi: 10.1371/journal.pone.0246295. eCollection 2021.
Since December 2019, the coronavirus disease (COVID-19) pandemic has catapulted the world into a marked health crisis, with over 29 million cases and >930,000 deaths. To better detect affected individuals at an early stage and stop disease progression to an advanced stage, several studies have been conducted to identify the clinical, biological, and radiological characteristics of COVID-19. This study aimed to enrich the literature by critically analyzing the clinical and biological characteristics of 134 patients from the North African Mediterranean region, including numerous genetic, epigenetic, and environmental factors that may influence disease evolution. This single-center retrospective study included all patients older than 18 years confirmed to have COVID-19 and hospitalized at the Cheikh Khalifa University Hospital affiliated with Mohammed VI University of Health Sciences, Casablanca, Morocco. Clinical, demographic, and biological data were analyzed in a cohort of severe and non-severe patients. Univariate analysis was performed to identify factors predictive of severity. There were 134 patients: the median age was 53 years, and 54.5% were male. Of these, 89 had mild to moderate disease; 45 had severe to critical disease, of which 14 died and 31 survived. Advanced age, presence of comorbidities, male sex, and infection in ethnic or family groups were risk factors for progression to severe disease. The presence of abnormalities in the following parameters were strongly associated with progression to severe disease: white blood cells (WBC), neutrophils, lymphocytes, C-reactive protein (CRP), procalcitonin, D-dimers, lactate dehydrogenase (LDH), ferritin, creatinine, aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT) during both admission and hospitalization. Based on these results and an extensive literature review, we recommend that clinicians closely monitor the biological parameters identified herein and perform immunological and genetic studies.
自 2019 年 12 月以来，冠状病毒病（COVID-19）大流行使世界陷入严重的卫生危机，病例超过 2900 万例，死亡人数超过 93 万。为了更好地在早期发现受影响的个体，并阻止疾病进展到晚期，已经进行了几项研究以确定 COVID-19 的临床、生物学和影像学特征。本研究旨在通过批判性分析来自北非地中海地区的 134 名患者的临床和生物学特征来丰富文献，包括许多可能影响疾病演变的遗传、表观遗传和环境因素。这项单中心回顾性研究纳入了所有在摩洛哥穆罕默德六世健康科学大学附属谢赫哈利法大学医院住院的年龄大于 18 岁并确诊为 COVID-19 的患者。对严重和非严重患者的队列进行了临床、人口统计学和生物学数据分析。进行了单变量分析以确定严重程度的预测因素。共有 134 名患者：中位年龄为 53 岁，54.5%为男性。其中 89 例为轻至中度疾病；45 例为严重至危急疾病，其中 14 例死亡，31 例存活。高龄、合并症、男性和族裔或家庭群体中的感染是疾病进展为严重疾病的危险因素。以下参数的异常存在与疾病进展为严重疾病密切相关：白细胞（WBC）、中性粒细胞、淋巴细胞、C 反应蛋白（CRP）、降钙素原、D-二聚体、乳酸脱氢酶（LDH）、铁蛋白、肌酐、天门冬氨酸氨基转移酶（ASAT）和丙氨酸氨基转移酶（ALAT）在入院和住院期间均存在。基于这些结果和广泛的文献综述，我们建议临床医生密切监测本文中确定的生物学参数，并进行免疫和遗传研究。
