Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA.
Department of Rehabilitation and Movement Sciences, Rutgers University, Newark, New Jersey, USA.
Sci Data. 2021 Feb 5;8(1):48. doi: 10.1038/s41597-021-00830-0.
Parkinson's disease (PD) is a neurodegenerative disorder associated with motor and non-motor symptoms. Current treatments primarily focus on managing motor symptom severity such as tremor, bradykinesia, and rigidity. However, as the disease progresses, treatment side-effects can emerge such as on/off periods and dyskinesia. The objective of the Levodopa Response Study was to identify whether wearable sensor data can be used to objectively quantify symptom severity in individuals with PD exhibiting motor fluctuations. Thirty-one subjects with PD were recruited from 2 sites to participate in a 4-day study. Data was collected using 2 wrist-worn accelerometers and a waist-worn smartphone. During Days 1 and 4, a portion of the data was collected in the laboratory while subjects performed a battery of motor tasks as clinicians rated symptom severity. The remaining of the recordings were performed in the home and community settings. To our knowledge, this is the first dataset collected using wearable accelerometers with specific focus on individuals with PD experiencing motor fluctuations that is made available via an open data repository.
帕金森病（PD）是一种与运动和非运动症状相关的神经退行性疾病。目前的治疗方法主要集中在管理运动症状的严重程度，如震颤、运动迟缓以及僵硬。然而，随着疾病的进展，治疗的副作用也会出现，如开-关期和运动障碍。左旋多巴反应研究的目的是确定可穿戴传感器数据是否可用于客观量化表现出运动波动的 PD 个体的症状严重程度。从 2 个地点招募了 31 名 PD 患者参加为期 4 天的研究。使用 2 个腕戴式加速度计和 1 个腰戴式智能手机来收集数据。在第 1 天和第 4 天，一部分数据在实验室中收集，同时患者在临床医生评估症状严重程度时执行一系列运动任务。其余的记录则在家庭和社区环境中进行。据我们所知，这是第一个使用可穿戴式加速度计收集的数据集，专门针对经历运动波动的 PD 患者，通过开放数据存储库提供。
